Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1842187..1842913 Replicon chromosome
Accession NZ_CP023270
Organism Achromobacter spanius strain MYb73

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag CLM73_RS08295 Protein ID WP_105238045.1
Coordinates 1842620..1842913 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag CLM73_RS08290 Protein ID WP_105238044.1
Coordinates 1842187..1842531 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLM73_RS08260 1838612..1838851 - 240 WP_105238039.1 6-phosphofructokinase -
CLM73_RS08265 1838948..1839856 + 909 WP_105238040.1 aromatic amino acid DMT transporter YddG -
CLM73_RS08270 1839885..1840076 - 192 WP_105238041.1 hypothetical protein -
CLM73_RS08275 1840337..1840588 + 252 WP_105238042.1 hypothetical protein -
CLM73_RS08280 1840697..1840888 + 192 WP_056567236.1 hypothetical protein -
CLM73_RS08285 1841090..1842013 + 924 WP_105238043.1 hypothetical protein -
CLM73_RS08290 1842187..1842531 - 345 WP_105238044.1 putative addiction module antidote protein Antitoxin
CLM73_RS08295 1842620..1842913 - 294 WP_105238045.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CLM73_RS08305 1843348..1844664 - 1317 WP_105238046.1 ergothioneine biosynthesis protein EgtB -
CLM73_RS08310 1844701..1845678 - 978 WP_105238047.1 L-histidine N(alpha)-methyltransferase -
CLM73_RS08315 1846051..1846386 + 336 WP_056567225.1 DUF883 family protein -
CLM73_RS08320 1846396..1847904 + 1509 WP_105238048.1 cardiolipin synthase B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10857.18 Da        Isoelectric Point: 9.3736

>T80691 WP_105238045.1 NZ_CP023270:c1842913-1842620 [Achromobacter spanius]
MKELESTEDYDKFEADLKDLRARAKIQARIQRLRAGNPGDHRNLEKGVSELRVDVGPGYRVYYTQRQDGTLVILLAGGSK
SSQQTDIASAYRLASSL

Download         Length: 294 bp

>T80691 NZ_CP023270:c1842913-1842620 [Achromobacter spanius]
ATGAAAGAACTGGAAAGCACCGAAGACTATGACAAGTTCGAAGCAGATTTGAAGGATCTGCGGGCTCGGGCGAAAATTCA
GGCGCGCATTCAACGACTGCGTGCCGGCAATCCAGGAGACCACCGAAACCTTGAAAAAGGCGTATCGGAACTTCGGGTTG
ATGTCGGTCCAGGATATAGGGTCTATTACACGCAGCGGCAGGACGGAACGCTTGTAATCCTTCTTGCAGGGGGCAGCAAG
TCATCGCAACAGACTGACATTGCAAGCGCTTACCGATTGGCCTCGAGCCTTTAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12104.90 Da        Isoelectric Point: 6.3148

>AT80691 WP_105238044.1 NZ_CP023270:c1842531-1842187 [Achromobacter spanius]
MAKLQTKKYDIAERLRTAEEMALYLDACIEESDGDAAFIAKALGDIARAQGMTKIAKDTGMSRESLYKALSGERSPDFAT
ILKVMGALGISFRAAATPRPNADTAAFGNIACPG

Download         Length: 345 bp

>AT80691 NZ_CP023270:c1842531-1842187 [Achromobacter spanius]
ATGGCAAAGCTTCAAACAAAAAAATACGACATCGCAGAGCGGCTTCGTACAGCCGAGGAAATGGCGCTTTATCTGGACGC
CTGCATCGAGGAAAGTGATGGCGATGCCGCGTTCATTGCAAAAGCACTCGGAGATATCGCTCGTGCGCAAGGTATGACGA
AGATCGCCAAGGACACAGGCATGTCGCGCGAAAGCCTGTATAAGGCGCTTTCCGGAGAGCGCTCTCCCGACTTCGCCACG
ATTCTCAAGGTCATGGGAGCGTTGGGAATTTCTTTCCGGGCAGCCGCCACCCCTCGACCGAATGCTGACACCGCTGCGTT
TGGCAACATCGCCTGCCCTGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References