Detailed information of TA system TA080690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 5091011..5091516
• Replicon: chromosome
• Accession: NZ_CP023269
• Organism: Pseudomonas sp. MYb193

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CLM72_RS23260
• Protein ID: WP_105228383.1
• Coordinates: 5091262..5091516 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: I4K3F7
• Locus tag: CLM72_RS23255
• Protein ID: WP_003194039.1
• Coordinates: 5091011..5091265 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CLM72_RS28855	5086074..5086295	+	222	WP_146120488.1	hypothetical protein	-
CLM72_RS23240	5086453..5088352	+	1900	Protein_4449	alkaline phosphatase family protein	-
CLM72_RS23245	5088490..5089503	+	1014	WP_105228379.1	sensor domain-containing diguanylate cyclase	-
CLM72_RS23250	5089613..5090866	+	1254	WP_105228381.1	aspartate aminotransferase family protein	-
CLM72_RS23255	5091011..5091265	+	255	WP_003194039.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CLM72_RS23260	5091262..5091516	+	255	WP_105228383.1	Txe/YoeB family addiction module toxin	Toxin
CLM72_RS23265	5091615..5092331	+	717	WP_034128720.1	hypothetical protein	-
CLM72_RS23270	5092381..5093580	-	1200	WP_177430943.1	MFS transporter	-
CLM72_RS23275	5093756..5094463	-	708	WP_105228385.1	autoinducer binding domain-containing protein	-
CLM72_RS23280	5094548..5095630	-	1083	WP_105228387.1	pyridoxal phosphate-dependent aminotransferase	-
CLM72_RS23285	5095842..5096447	+	606	WP_080757657.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10059.52 Da
• Isoelectric Point: 7.2753

>T80690 WP_105228383.1 NZ_CP023269:5091262-5091516 [Pseudomonas sp. MYb193]
MKILFTSEGWDDYLWFQQNDKAGLKRINFLIKAIQRDPFDGVGKPEPLKHNLSGFWSRRITAEHRLVYGIEDDEVQILMC
RYHY

Nucleotide

• Length: 255 bp

>T80690 NZ_CP023269:5091262-5091516 [Pseudomonas sp. MYb193]
ATGAAAATACTCTTTACCTCTGAAGGCTGGGACGACTACCTCTGGTTTCAACAGAACGACAAAGCCGGGCTCAAGCGCAT
CAATTTCTTGATCAAGGCCATACAAAGAGACCCGTTCGACGGCGTGGGAAAGCCTGAACCCCTCAAACATAACCTGAGTG
GTTTCTGGTCTAGACGAATCACCGCGGAGCATCGTTTGGTTTATGGCATCGAGGATGATGAAGTACAAATATTGATGTGC
CGCTATCACTACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9576.93 Da
• Isoelectric Point: 7.2034

>AT80690 WP_003194039.1 NZ_CP023269:5091011-5091265 [Pseudomonas sp. MYb193]
METINYTNARAHLSETMDRVNDDHVPLLLTRQKGEPVVMISLSEFNALEETAYLLRSPKNAERLINSVNSLRAGKAKPRR
LIEE

Nucleotide

• Length: 255 bp

>AT80690 NZ_CP023269:5091011-5091265 [Pseudomonas sp. MYb193]
ATGGAAACTATCAACTACACCAACGCCCGAGCCCATCTGTCCGAAACGATGGACCGCGTCAACGATGATCACGTCCCACT
TCTACTGACTCGACAAAAAGGCGAGCCCGTGGTGATGATCTCGTTATCAGAGTTCAATGCTCTGGAAGAGACGGCTTACC
TGCTGCGCTCGCCTAAAAATGCCGAACGTCTCATTAACTCAGTCAACAGCTTACGAGCAGGCAAAGCCAAGCCAAGGCGG
TTGATTGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0W0MVN5