Detailed information of TA system TA080687

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 2562837..2563447
• Replicon: chromosome
• Accession: NZ_CP023269
• Organism: Pseudomonas sp. MYb193

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CLM72_RS11980
• Protein ID: WP_105226583.1
• Coordinates: 2563196..2563447 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CLM72_RS11975
• Protein ID: WP_105226582.1
• Coordinates: 2562837..2563199 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CLM72_RS11955	2558348..2559703	+	1356	WP_105226578.1	MATE family efflux transporter	-
CLM72_RS11960	2559687..2560274	-	588	WP_105226579.1	TetR/AcrR family transcriptional regulator	-
CLM72_RS11965	2560407..2561579	+	1173	WP_105226580.1	MFS transporter	-
CLM72_RS11970	2561593..2562597	-	1005	WP_146120474.1	Camphene synthase	-
CLM72_RS11975	2562837..2563199	-	363	WP_105226582.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CLM72_RS11980	2563196..2563447	-	252	WP_105226583.1	type II toxin-antitoxin system HicA family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9478.05 Da
• Isoelectric Point: 10.0459

>T80687 WP_105226583.1 NZ_CP023269:c2563447-2563196 [Pseudomonas sp. MYb193]
VSKNEKLLAKLLNEHMAFTWSELVTLLRRLGYTQIEGAGSRVKFDIGDPGAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Nucleotide

• Length: 252 bp

>T80687 NZ_CP023269:c2563447-2563196 [Pseudomonas sp. MYb193]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTCAATGAGCACATGGCATTTACCTGGTCTGAGCTCGTCACGTTATT
ACGCCGATTGGGATACACACAGATTGAAGGGGCTGGAAGCCGGGTCAAGTTCGACATTGGCGACCCCGGTGCAATGATCA
CCCTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGCCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 12999.86 Da
• Isoelectric Point: 6.8522

>AT80687 WP_105226582.1 NZ_CP023269:c2563199-2562837 [Pseudomonas sp. MYb193]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFKEAVEDYLTTCQALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQQHGAEGLAAV

Nucleotide

• Length: 363 bp

>AT80687 NZ_CP023269:c2563199-2562837 [Pseudomonas sp. MYb193]
GTGAACAACCAACTGAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAAGACAACTGCCTGTTCGGCAAGAT
CCTCTTCATCAAGGCGCTGGTGAGCTACGAAGGCAAGACGGTCGCAGAGTTGGACGCCGCGTTCAAAGAGGCGGTGGAGG
ATTACCTCACTACGTGCCAGGCCCTGGGCCAGACACCCGAGAAACCCTGCAAGGGTTCATTCAACGTGCGTGTCGGCCAC
GACCTGCACCTGGCTGCGGCCCTGGCGGCGACTCGAAAAAAAGTAACGTTGAACGACCTCACGCGCCAGGCGCTCAACGA
GTTCCTGCAGCAACATGGCGCAGAGGGGCTTGCCGCCGTTTGA