Detailed information of TA system TA080677

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1084057..1084688
• Replicon: chromosome
• Accession: NZ_CP023268
• Organism: Serratia sp. MYb239

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: L0MF14
• Locus tag: CLM71_RS05110
• Protein ID: WP_015671220.1
• Coordinates: 1084057..1084260 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: CLM71_RS05115
• Protein ID: WP_105230044.1
• Coordinates: 1084320..1084688 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CLM71_RS05090	1079253..1079675	+	423	WP_158684783.1	hypothetical protein	-
CLM71_RS05095	1079710..1081053	-	1344	WP_105230041.1	NCS2 family permease	-
CLM71_RS05100	1081123..1082910	-	1788	WP_105230042.1	adenine deaminase	-
CLM71_RS05105	1083049..1083981	+	933	WP_105230043.1	LysR family transcriptional regulator	-
CLM71_RS05110	1084057..1084260	-	204	WP_015671220.1	hemolysin expression modulator Hha	Toxin
CLM71_RS05115	1084320..1084688	-	369	WP_105230044.1	Hha toxicity modulator TomB	Antitoxin
CLM71_RS05120	1085064..1085417	-	354	WP_105230045.1	hypothetical protein	-
CLM71_RS23875	1085675..1085821	+	147	WP_158684784.1	hypothetical protein	-
CLM71_RS05125	1085818..1086522	+	705	WP_105230046.1	ABC transporter ATP-binding protein	-
CLM71_RS05130	1086519..1087385	+	867	WP_105230047.1	metal ABC transporter permease	-
CLM71_RS05135	1087401..1088276	+	876	WP_105230048.1	metal ABC transporter substrate-binding protein	-
CLM71_RS05140	1088375..1088515	-	141	WP_004940304.1	type B 50S ribosomal protein L36	-
CLM71_RS05145	1088525..1088779	-	255	WP_015671227.1	type B 50S ribosomal protein L31	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8049.33 Da
• Isoelectric Point: 7.9816

>T80677 WP_015671220.1 NZ_CP023268:c1084260-1084057 [Serratia sp. MYb239]
MTKTDYLMRLRKCTTIDTLERVIEKNKYALSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Nucleotide

• Length: 204 bp

>T80677 NZ_CP023268:c1084260-1084057 [Serratia sp. MYb239]
ATGACAAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACTATAGATACTCTTGAGAGAGTGATTGAAAAAAACAA
GTACGCGCTATCCGATGATGAGCTAGAACTGTTTTACTCCGCAGCCGATCACCGTCTGGCGGAACTCACCATGAATAAGC
TGTACGACAAAATCCCAACGTCTGTTTGGAAATATGTAAGATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14350.17 Da
• Isoelectric Point: 4.6346

>AT80677 WP_105230044.1 NZ_CP023268:c1084688-1084320 [Serratia sp. MYb239]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSYKIKYMDESDFSELVEEYL
DDTYTLFSNYGINDSDLRRWQKTKLRLFRMFSGEVCCTKMKT

Nucleotide

• Length: 369 bp

>AT80677 NZ_CP023268:c1084688-1084320 [Serratia sp. MYb239]
ATGGATGAGTACTCGCCGAAACGGCATGATATTGCTCAACTCAAATTCTTGTGTGAAAATTTGTACGATGAAGGCATCGC
GACGTTGGGCGACAGTCACCACGGCTGGGTCAACGATCCGACATCGGCCGTCAACCTGCAACTGAATGAACTGATCGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATAAAATACATGGATGAAAGTGATTTTTCAGAATTGGTCGAAGAGTATCTC
GACGATACCTACACGTTATTTAGTAACTACGGTATTAACGATTCCGATCTGCGCCGTTGGCAAAAAACCAAACTGCGATT
ATTCAGAATGTTCTCAGGAGAGGTTTGCTGTACGAAAATGAAAACTTAG

Structures

Toxin

• AlphaFold DB: A0A857EAE6