Detailed information of TA system TA080671

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 2254531..2255072
• Replicon: chromosome
• Accession: NZ_CP023256
• Organism: Alcaligenes faecalis strain c16

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CLH39_RS10295
• Protein ID: WP_149721200.1
• Coordinates: 2254797..2255072 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CLH39_RS10290
• Protein ID: WP_149721199.1
• Coordinates: 2254531..2254797 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CLH39_RS10265	2249915..2250808	-	894	WP_149721194.1	hypothetical protein	-
CLH39_RS10270	2250820..2251419	-	600	WP_203144612.1	hypothetical protein	-
CLH39_RS10275	2251432..2252190	-	759	WP_203144613.1	DsbC family protein	-
CLH39_RS10280	2252212..2252721	-	510	WP_203144614.1	PH domain-containing protein	-
CLH39_RS10285	2252793..2253599	-	807	WP_203144615.1	SprT-like domain-containing protein	-
CLH39_RS10290	2254531..2254797	+	267	WP_149721199.1	ribbon-helix-helix domain-containing protein	Antitoxin
CLH39_RS10295	2254797..2255072	+	276	WP_149721200.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CLH39_RS10300	2255176..2255394	+	219	WP_149721201.1	DUF3018 family protein	-
CLH39_RS10305	2255441..2255659	+	219	WP_149721202.1	hypothetical protein	-
CLH39_RS10310	2255900..2256892	+	993	WP_203144616.1	hypothetical protein	-
CLH39_RS10315	2256903..2257544	-	642	WP_149721204.1	hypothetical protein	-
CLH39_RS10320	2257710..2259338	-	1629	WP_203144617.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
CLH39_RS10325	2259353..2259754	-	402	WP_009454051.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2197161..2293477	96316

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (8-45)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10821.69 Da
• Isoelectric Point: 10.3092

>T80671 WP_149721200.1 NZ_CP023256:2254797-2255072 [Alcaligenes faecalis]
MKLKWTSKALSDLERLYEFLAVVNKPAAARAVQKLAKAPSILLSNPRIGEQLFMFEPREVRRILVGEYEIRYELQDSFIY
VLRIWHTRENR

Nucleotide

• Length: 276 bp

>T80671 NZ_CP023256:2254797-2255072 [Alcaligenes faecalis]
ATGAAATTAAAGTGGACTAGTAAGGCGCTTTCTGATTTAGAGCGTCTGTATGAGTTTTTGGCCGTGGTGAATAAACCAGC
TGCTGCTCGTGCCGTGCAGAAACTGGCCAAGGCCCCGAGCATTTTACTGAGCAATCCACGCATTGGTGAGCAGCTCTTTA
TGTTTGAGCCACGTGAGGTAAGGCGAATTCTGGTCGGAGAGTATGAAATTCGCTATGAGCTTCAGGATTCGTTTATCTAC
GTGCTTCGGATATGGCACACCCGAGAAAATCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9806.27 Da
• Isoelectric Point: 6.4561

>AT80671 WP_149721199.1 NZ_CP023256:2254531-2254797 [Alcaligenes faecalis]
MTASTKVLTAHVPLPLATKVDQMAARLDRSRGWIMKQALSAWIAQEEERTRLTQEALVDVDKGCVIDHQAVQAWAESLGT
EQQLPLPR

Nucleotide

• Length: 267 bp

>AT80671 NZ_CP023256:2254531-2254797 [Alcaligenes faecalis]
ATGACAGCATCAACTAAGGTACTTACCGCACATGTACCGCTTCCGTTGGCTACCAAGGTAGACCAGATGGCTGCTCGGCT
TGATCGCTCGCGTGGCTGGATCATGAAGCAGGCTCTTTCAGCCTGGATAGCCCAAGAAGAGGAGCGCACAAGACTGACCC
AAGAGGCGTTGGTTGATGTTGACAAGGGTTGTGTCATTGACCACCAAGCTGTACAGGCTTGGGCTGAGAGCCTTGGTACT
GAGCAGCAGTTGCCACTGCCACGCTGA