80669

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 4931801..4932306 Replicon chromosome
Accession NZ_CP023255
Organism Pseudomonas aeruginosa strain CCUG 70744

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag CLH63_RS23800 Protein ID WP_003083773.1
Coordinates 4931801..4932082 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag CLH63_RS23805 Protein ID WP_003083775.1
Coordinates 4932079..4932306 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLH63_RS23775 4927052..4928401 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
CLH63_RS23780 4928450..4929136 + 687 WP_003083762.1 FadR family transcriptional regulator -
CLH63_RS23785 4929237..4929971 + 735 WP_003117208.1 GntR family transcriptional regulator -
CLH63_RS23790 4930175..4930561 + 387 WP_003083767.1 aegerolysin family protein -
CLH63_RS23795 4930593..4931501 - 909 WP_003083769.1 LysR family transcriptional regulator -
CLH63_RS23800 4931801..4932082 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
CLH63_RS23805 4932079..4932306 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
CLH63_RS23810 4932482..4933102 - 621 WP_031298866.1 hypothetical protein -
CLH63_RS23815 4933203..4933703 + 501 WP_003101228.1 LEA type 2 family protein -
CLH63_RS23820 4933776..4934117 + 342 WP_003101229.1 alkylphosphonate utilization protein -
CLH63_RS23825 4934199..4935626 - 1428 WP_023464187.1 GABA permease -
CLH63_RS23830 4935795..4937288 - 1494 WP_016263977.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T80669 WP_003083773.1 NZ_CP023255:c4932082-4931801 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T80669 NZ_CP023255:c4932082-4931801 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT80669 WP_003083775.1 NZ_CP023255:c4932306-4932079 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT80669 NZ_CP023255:c4932306-4932079 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References