Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 511428..511981 Replicon chromosome
Accession NZ_CP023255
Organism Pseudomonas aeruginosa strain CCUG 70744

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag CLH63_RS02705 Protein ID WP_010953434.1
Coordinates 511688..511981 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q88JZ4
Locus tag CLH63_RS02700 Protein ID WP_010953433.1
Coordinates 511428..511700 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLH63_RS02670 507000..507359 - 360 Protein_512 DNA repair protein RadC -
CLH63_RS02675 507331..508281 - 951 WP_031299400.1 hypothetical protein -
CLH63_RS02680 508374..509378 - 1005 WP_010953429.1 YqaJ viral recombinase family protein -
CLH63_RS02685 509458..510426 - 969 WP_031299399.1 DUF932 domain-containing protein -
CLH63_RS02690 510524..510796 - 273 WP_031299398.1 hypothetical protein -
CLH63_RS02695 511058..511303 + 246 WP_010953432.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CLH63_RS02700 511428..511700 + 273 WP_010953433.1 CopG family ribbon-helix-helix protein Antitoxin
CLH63_RS02705 511688..511981 + 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CLH63_RS02710 511975..513384 - 1410 WP_010953435.1 site-specific integrase -
CLH63_RS02715 513822..516602 + 2781 WP_023464835.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 489609..587047 97438


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T80664 WP_010953434.1 NZ_CP023255:511688-511981 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

>T80664 NZ_CP023255:511688-511981 [Pseudomonas aeruginosa]
GTGCCACGACTGATCGTCACTGAAGGCGCGGCGAAGGGCCTGGAGCGTTGCCGGCGATTTCTCTCCGATAAAGATCCGCA
GGTCGCACGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCTTTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10373.53 Da        Isoelectric Point: 5.5744

>AT80664 WP_010953433.1 NZ_CP023255:511428-511700 [Pseudomonas aeruginosa]
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp

>AT80664 NZ_CP023255:511428-511700 [Pseudomonas aeruginosa]
ATGGCCACTTCCATCAAAATTGACGACGATCTGAAAGGTCGCATTCAGCATTTGGCTTGTTTGCGCCAGCGCTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCATACCAGGAAACCGGCCAGCACTTGACCGGCCAGGAGGCTCGCACCTGGCTTGGTAGTTGGGGTACAGAT
GCTGAGGCAGAGTTACCCAAGTGCCACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB Q88JZ4

References