Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 587506..588034 Replicon chromosome
Accession NZ_CP023209
Organism Vibrio anguillarum strain ATCC-68554

Toxin (Protein)


Gene name relE Uniprot ID F7YRA6
Locus tag CLI14_RS17165 Protein ID WP_013868556.1
Coordinates 587506..587793 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F7YRA5
Locus tag CLI14_RS17170 Protein ID WP_013868555.1
Coordinates 587783..588034 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLI14_RS17120 582560..583027 - 468 WP_001289286.1 OsmC family protein -
CLI14_RS17125 583184..583624 - 441 WP_040122767.1 hypothetical protein -
CLI14_RS17135 584315..584674 - 360 WP_019281417.1 VOC family protein -
CLI14_RS17145 585874..586158 + 285 WP_017040620.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
CLI14_RS17150 586155..586433 + 279 WP_010320663.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
CLI14_RS17165 587506..587793 - 288 WP_013868556.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CLI14_RS17170 587783..588034 - 252 WP_013868555.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CLI14_RS17180 588248..588733 - 486 WP_107489895.1 hypothetical protein -
CLI14_RS17190 588980..589813 + 834 Protein_535 IS30-like element ISVa6 family transposase -
CLI14_RS17195 589896..590213 + 318 WP_011154648.1 IS66 family insertion sequence hypothetical protein -
CLI14_RS17200 590210..590563 + 354 WP_011154649.1 IS66 family insertion sequence element accessory protein TnpB -
CLI14_RS17205 590623..592164 + 1542 WP_011154650.1 IS66-like element ISVa5 family transposase -
CLI14_RS17210 592523..592798 - 276 WP_013868550.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 581977..597337 15360


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-70)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11064.07 Da        Isoelectric Point: 10.5506

>T80639 WP_013868556.1 NZ_CP023209:c587793-587506 [Vibrio anguillarum]
MTYKLKFLPAAKKEWSKLAPPIQSQFKKKLKERLENPHVPSSKLRGYDSVYKIKLRTAGYRLAYEVIDDEIVVYVLAIGK
RDKDAVYKKLASRFS

Download         Length: 288 bp

>T80639 NZ_CP023209:c587793-587506 [Vibrio anguillarum]
ATGACTTATAAGCTAAAATTTCTACCGGCTGCCAAGAAAGAGTGGAGTAAGTTAGCTCCACCAATTCAAAGTCAGTTCAA
AAAGAAGCTTAAAGAGCGTCTGGAAAACCCGCATGTTCCTTCTTCTAAACTGCGTGGCTATGACTCAGTTTATAAGATCA
AACTACGTACAGCAGGCTATCGCTTAGCCTATGAAGTCATTGATGATGAAATCGTGGTGTACGTGTTAGCTATTGGAAAA
CGAGATAAAGATGCAGTGTACAAAAAGTTAGCATCAAGGTTCTCGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9154.36 Da        Isoelectric Point: 4.0414

>AT80639 WP_013868555.1 NZ_CP023209:c588034-587783 [Vibrio anguillarum]
MRQVLADCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEFLMDMLDDYELAKLVESRRGELSEAVEVNI
DDL

Download         Length: 252 bp

>AT80639 NZ_CP023209:c588034-587783 [Vibrio anguillarum]
ATGAGACAGGTTTTAGCTGATTGTTCTGCAAGTATTTCTGAGTTAAAGAAAAATCCAACCGCTTTACTAAACGAAGCTGA
TGGTTCTGCCATTGCTATTCTAAACCACAATAAGCCAGCAGCTTATCTTGTCCCAGCAGAAACTTATGAGTTTCTAATGG
ATATGCTCGATGACTATGAGCTTGCTAAACTAGTTGAAAGTCGCCGTGGTGAATTGTCTGAAGCGGTGGAAGTAAATATC
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E5BHG0

Antitoxin

Source ID Structure
AlphaFold DB A0A7X8TZB8

References