Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 585874..586433 Replicon chromosome
Accession NZ_CP023209
Organism Vibrio anguillarum strain ATCC-68554

Toxin (Protein)


Gene name relE Uniprot ID F7YRQ7
Locus tag CLI14_RS17150 Protein ID WP_010320663.1
Coordinates 586155..586433 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A233HRF0
Locus tag CLI14_RS17145 Protein ID WP_017040620.1
Coordinates 585874..586158 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLI14_RS17120 582560..583027 - 468 WP_001289286.1 OsmC family protein -
CLI14_RS17125 583184..583624 - 441 WP_040122767.1 hypothetical protein -
CLI14_RS17135 584315..584674 - 360 WP_019281417.1 VOC family protein -
CLI14_RS17145 585874..586158 + 285 WP_017040620.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CLI14_RS17150 586155..586433 + 279 WP_010320663.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CLI14_RS17165 587506..587793 - 288 WP_013868556.1 type II toxin-antitoxin system RelE/ParE family toxin -
CLI14_RS17170 587783..588034 - 252 WP_013868555.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CLI14_RS17180 588248..588733 - 486 WP_107489895.1 hypothetical protein -
CLI14_RS17190 588980..589813 + 834 Protein_535 IS30-like element ISVa6 family transposase -
CLI14_RS17195 589896..590213 + 318 WP_011154648.1 IS66 family insertion sequence hypothetical protein -
CLI14_RS17200 590210..590563 + 354 WP_011154649.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 581977..597337 15360


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-44)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10878.58 Da        Isoelectric Point: 4.3430

>T80638 WP_010320663.1 NZ_CP023209:586155-586433 [Vibrio anguillarum]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDDIIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGSIIRIM
RVLHQKQKFPTD

Download         Length: 279 bp

>T80638 NZ_CP023209:586155-586433 [Vibrio anguillarum]
ATGATTTTATGGGAAGAGGAATCGCTAAATGATCGTGAGAAGATCTTTGAGTTTCTTTATGACTTTAACCCTGATGCGGC
TGAAAAAACTGATGACATTATTGAGGCTAAAGTAGAAAACTTACTCGAACAACCATTGATGGGTGTTCAACGGGATGGAA
TTCGAGGACGATTACTCATTATTCCCGAAATCTCAATGATCGTTTCGTACTGGGTAGAAGGTTCAATTATTCGCATAATG
CGAGTTCTACACCAGAAGCAGAAATTCCCTACCGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10957.29 Da        Isoelectric Point: 9.2173

>AT80638 WP_017040620.1 NZ_CP023209:585874-586158 [Vibrio anguillarum]
MDTRIQFRVDDEIKRLAQQMAESQGRTLSDACRELTEQMAEQQRKTLSHDAWLTEQINLAFEKFDSGKSSFVEHNSAKAR
MAERKAKIRNRGQQ

Download         Length: 285 bp

>AT80638 NZ_CP023209:585874-586158 [Vibrio anguillarum]
ATGGACACTCGAATTCAATTTCGTGTTGATGACGAAATTAAACGTTTAGCCCAACAAATGGCTGAGAGCCAAGGTCGCAC
ACTCAGCGATGCTTGCCGTGAACTTACTGAACAAATGGCTGAGCAACAAAGAAAAACATTATCTCATGACGCTTGGTTAA
CTGAACAAATAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTTCATTTGTTGAACATAATTCAGCTAAAGCACGA
ATGGCTGAACGAAAGGCCAAAATTCGTAATCGAGGCCAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F2IQF3

Antitoxin

Source ID Structure
AlphaFold DB A0A233HRF0

References