Detailed information of TA system TA080635

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 160761..162483
• Replicon: chromosome
• Accession: NZ_CP023208
• Organism: Vibrio anguillarum strain ATCC-68554

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: F7YIZ5
• Locus tag: CLI14_RS00750
• Protein ID: WP_013855709.1
• Coordinates: 161545..162483 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: CLI14_RS00745
• Protein ID: WP_013855708.1
• Coordinates: 160761..161552 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CLI14_RS00730	158292..158516	-	225	WP_001147121.1	hypothetical protein	-
CLI14_RS00735	158517..158801	-	285	WP_013855706.1	helix-turn-helix domain-containing protein	-
CLI14_RS00740	158798..160491	-	1694	Protein_131	DUF927 domain-containing protein	-
CLI14_RS00745	160761..161552	+	792	WP_013855708.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
CLI14_RS00750	161545..162483	+	939	WP_013855709.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
CLI14_RS00755	162522..164669	+	2148	WP_013855710.1	site-specific DNA-methyltransferase	-
CLI14_RS00760	164672..167272	+	2601	WP_013855711.1	DEAD/DEAH box helicase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	160761..173269	12508

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35361.46 Da
• Isoelectric Point: 4.7638

>T80635 WP_013855709.1 NZ_CP023208:161545-162483 [Vibrio anguillarum]
MDRESPYYKQVSLLIRMLPVVATEPSFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRNEALANVKAALQRITDLINKE
PENRAVLQDHRLDELRIVVTSPNATIKIEVSPVARGTLHKPDSLAVQESVEEEFGYAEIPVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLAEEGISRDIFVGFITYVLSHPRPINEVMAPNWQPLDDKFQAEFDGMTFEPVELNDLISTRPAMVAALQA
HFTEKDRSFLLSFKQGNPDWSLFDYPDAAELPAIRWKLQNIAKLAKNQEKHVEQLTKLESVLDDWLKQANSN

Nucleotide

• Length: 939 bp

>T80635 NZ_CP023208:161545-162483 [Vibrio anguillarum]
ATGGATAGAGAGAGCCCTTATTACAAGCAGGTTTCACTGCTGATTAGAATGTTACCAGTGGTTGCAACAGAACCTTCATT
TGCACTTAAAGGTGGTACAGCTATCAACTTATTTGTGAGGGATTTTCCACGCTTGTCTGTGGATATTGATCTTGCTTATC
TTCCTCTTGAGCCCCGAAATGAAGCTCTAGCAAATGTAAAAGCAGCATTGCAACGTATAACCGATTTAATCAACAAAGAA
CCTGAGAACCGAGCTGTATTGCAGGACCATAGGTTAGATGAATTGCGTATTGTTGTTACAAGTCCTAATGCAACAATTAA
AATAGAAGTCTCTCCGGTAGCAAGAGGTACGTTGCATAAACCTGATAGCTTAGCTGTCCAAGAATCAGTCGAAGAAGAGT
TTGGTTATGCAGAGATTCCTGTAGTTAGTCTGCCCGATCTTTATGGCGGAAAACTATGTGCTGCCATGGATCGCCAGCAC
CCTCGCGACCTGTTTGATGTTCGTATGCTGCTTGCAGAAGAAGGTATTTCACGAGATATCTTTGTTGGATTCATTACTTA
CGTACTAAGCCACCCAAGACCTATCAATGAGGTTATGGCTCCTAACTGGCAACCTCTTGATGATAAGTTTCAAGCTGAGT
TCGATGGCATGACCTTTGAACCCGTTGAGTTAAACGACTTAATTTCTACAAGGCCTGCGATGGTAGCTGCACTACAAGCC
CATTTCACAGAAAAAGATCGCTCATTTTTGTTGTCATTCAAACAAGGTAATCCTGATTGGTCACTGTTTGACTACCCAGA
TGCAGCAGAACTGCCAGCTATACGCTGGAAGCTACAAAACATAGCTAAGTTAGCTAAAAATCAAGAAAAACATGTAGAGC
AGCTAACTAAATTAGAGTCTGTACTTGATGATTGGCTTAAGCAAGCCAACTCCAATTAA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 29934.05 Da
• Isoelectric Point: 9.6742

>AT80635 WP_013855708.1 NZ_CP023208:160761-161552 [Vibrio anguillarum]
MSSKINWLVANAYPGALVLQQWLTENGISYSLAQKYAQSGWLRKLSSGVYYRPSARDDVKPGWVDALQAMDTQLHHRVHL
AGLSSLTHQGLSHYLQLSKEQVWIGVKNKQSLPKWFREFPNQNWFYCGNHKLEAVSDKDLKVITVKGKELKASCPELAAY
EVVDAIGKQISFEHAAELFQGLVNLSPRKVQSLLERSSSVQTNRVFLFLSHYHGHQWTQRIDETKIALGSGKRQVVEQGR
FDERYQITVPEILSVKKEEANNG

Nucleotide

• Length: 792 bp

>AT80635 NZ_CP023208:160761-161552 [Vibrio anguillarum]
ATGTCATCCAAGATAAACTGGTTGGTAGCCAATGCATATCCTGGAGCCCTTGTGCTACAGCAATGGCTGACTGAGAACGG
AATTAGCTATTCCTTAGCTCAAAAATATGCGCAGAGTGGTTGGCTTAGGAAGCTATCTTCTGGCGTTTATTATCGGCCAA
GCGCAAGAGATGATGTTAAGCCGGGCTGGGTGGATGCTCTACAAGCGATGGACACACAGTTGCACCATCGTGTTCATCTG
GCTGGGTTAAGCAGCTTAACTCACCAAGGGCTGAGCCACTATTTACAGCTAAGTAAAGAACAAGTTTGGATAGGGGTGAA
GAACAAACAATCATTGCCTAAGTGGTTTCGTGAATTTCCCAATCAAAATTGGTTTTATTGTGGTAACCATAAGCTTGAAG
CTGTCTCTGACAAGGACCTAAAAGTGATTACGGTTAAAGGAAAAGAGCTAAAAGCTAGTTGCCCAGAGCTTGCTGCTTAC
GAAGTTGTTGATGCAATCGGGAAGCAAATTTCTTTTGAGCATGCAGCAGAGCTTTTTCAAGGCCTCGTAAACCTGAGTCC
TAGAAAGGTGCAATCTCTTCTTGAACGTAGTAGCTCGGTTCAAACCAATAGAGTGTTTTTGTTCTTGAGTCATTATCATG
GGCATCAGTGGACTCAGCGCATTGATGAAACAAAGATCGCATTAGGTTCAGGAAAGCGTCAGGTGGTAGAGCAAGGGCGA
TTTGATGAGCGTTACCAAATCACTGTGCCAGAAATATTAAGTGTAAAAAAAGAAGAAGCAAACAATGGATAG

Structures

Toxin

• AlphaFold DB: F7YIZ5