Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1456291..1457066 Replicon chromosome
Accession NZ_CP023204
Organism Burkholderia glumae strain 336gr-1

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag CG017_RS22870 Protein ID WP_015877380.1
Coordinates 1456569..1457066 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag CG017_RS22865 Protein ID WP_015877381.1
Coordinates 1456291..1456572 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CG017_RS22855 (CG017_04501) 1455472..1455834 + 363 WP_017432434.1 hypothetical protein -
CG017_RS22860 1455917..1456294 + 378 WP_173941242.1 hypothetical protein -
CG017_RS22865 (CG017_04502) 1456291..1456572 + 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
CG017_RS22870 (CG017_04503) 1456569..1457066 + 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
CG017_RS22875 1457147..1457644 + 498 WP_015877379.1 ProQ/FINO family protein -
CG017_RS22880 1458058..1458660 + 603 Protein_1282 RHS domain-containing protein -
CG017_RS30780 1458790..1459041 + 252 WP_230674552.1 hypothetical protein -
CG017_RS22885 1459058..1459342 + 285 WP_153478924.1 hypothetical protein -
CG017_RS22890 (CG017_04505) 1459559..1461145 - 1587 WP_012732733.1 IS66 family transposase -
CG017_RS22895 (CG017_04506) 1461245..1461598 - 354 WP_012732734.1 IS66 family insertion sequence element accessory protein TnpB -
CG017_RS22900 (CG017_04507) 1461598..1462053 - 456 WP_012732735.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T80631 WP_015877380.1 NZ_CP023204:1456569-1457066 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

>T80631 NZ_CP023204:1456569-1457066 [Burkholderia glumae]
GTGACGGGCTGGCGCGCGCCCGAACCGCTCAGCGACGCGCACGGGCTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGCCGTGCACTGGCCAATCAGCGTAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGAG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGGCGCAACATGCCCGAT
CCGATACCGGTGGTTGTGCTCGGGCGTCTCGCCGTCGATCGCGCCCATCAGGGCATTGGGGTTGGGCGTGCGCTGGTACG
CGATGCCGGCTTGCGTGTGTTGCACGCCGCAGCGGCCATCGGGATTCGCGGCCTGATCGTGCATGCACTCTCGGACTCGG
CCAAGGCGTTCTATGAGCGGGTCGGCTTTGAGGCGTCGCCGCTCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTC
GAGCACGCCTTGTCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT80631 WP_015877381.1 NZ_CP023204:1456291-1456572 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp

>AT80631 NZ_CP023204:1456291-1456572 [Burkholderia glumae]
ATGACCTCGACCACCCCACGCGACACTCTGAACCTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTTCTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCCGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGTTTGGACGAGCCCGTCCAACCGAACGAGGCATTGCGC
CAGACCATGCAGACACGCGCGCCCTGGGACCCCGCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References