Detailed information of TA system TA080630

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2530431..2530959
• Replicon: chromosome
• Accession: NZ_CP023202
• Organism: Streptomyces xinghaiensis S187

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SXIN_RS10660
• Protein ID: WP_019710257.1
• Coordinates: 2530690..2530959 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SXIN_RS10655
• Protein ID: WP_019710256.1
• Coordinates: 2530431..2530697 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SXIN_RS10625	2526716..2527549	-	834	WP_039822532.1	ABC transporter ATP-binding protein	-
SXIN_RS10630	2527546..2528376	-	831	WP_019710251.1	zf-HC2 domain-containing protein	-
SXIN_RS10635	2528373..2528876	-	504	WP_202859817.1	RNA polymerase sigma factor	-
SXIN_RS10640	2529237..2529644	-	408	WP_039822539.1	hypothetical protein	-
SXIN_RS10645	2529794..2530141	-	348	Protein_2091	TetR/AcrR family transcriptional regulator C-terminal ligand-binding domain-containing protein	-
SXIN_RS10655	2530431..2530697	+	267	WP_019710256.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SXIN_RS10660	2530690..2530959	+	270	WP_019710257.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SXIN_RS31520	2531084..2531311	+	228	WP_192883578.1	hypothetical protein	-
SXIN_RS10670	2531380..2532086	-	707	Protein_2095	Fic family protein	-
SXIN_RS10675	2532121..2535309	-	3189	WP_019710259.1	CHAT domain-containing protein	-
SXIN_RS10680	2535456..2535845	+	390	WP_157916272.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10240.73 Da
• Isoelectric Point: 9.8427

>T80630 WP_019710257.1 NZ_CP023202:2530690-2530959 [Streptomyces xinghaiensis S187]
VSEYRTVFRPEAQAELRKAPRAMALRILAKLTELESDPLGYSTTALVSQPDRRRLRVGDYRIIYTIDNGELVVWVVHVGH
RSTVYESRP

Nucleotide

• Length: 270 bp

>T80630 NZ_CP023202:2530690-2530959 [Streptomyces xinghaiensis S187]
GTGAGTGAGTACCGCACCGTCTTCCGACCCGAGGCACAGGCCGAGCTTCGGAAAGCCCCCCGCGCCATGGCCCTGCGCAT
CCTTGCCAAGCTGACGGAACTGGAGAGTGACCCGCTCGGATACAGCACCACGGCGCTCGTGTCCCAGCCCGACCGCCGCC
GCCTCCGGGTCGGCGACTACCGCATCATCTACACCATCGACAACGGCGAACTCGTTGTATGGGTGGTTCATGTCGGCCAT
CGCTCCACGGTCTACGAGTCGCGACCGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10212.63 Da
• Isoelectric Point: 5.2171

>AT80630 WP_019710256.1 NZ_CP023202:2530431-2530697 [Streptomyces xinghaiensis S187]
MTQMPIESIRDVRAHLAEVVERADRDDQPTVITRRGKQVAAVVSIDVLRKYQQWEEREINRIIDERMANRSPGVPIEDVM
KETLARGE

Nucleotide

• Length: 267 bp

>AT80630 NZ_CP023202:2530431-2530697 [Streptomyces xinghaiensis S187]
ATGACACAGATGCCCATAGAGTCCATCCGTGACGTCCGCGCACACCTTGCGGAGGTCGTCGAACGGGCCGATCGCGATGA
CCAGCCCACCGTGATCACGCGACGAGGAAAGCAAGTCGCCGCTGTCGTCTCGATCGATGTTCTGCGCAAGTACCAACAGT
GGGAAGAGCGCGAGATCAACCGCATCATCGACGAGCGGATGGCAAACCGCTCGCCCGGCGTCCCCATCGAGGACGTCATG
AAGGAAACCCTGGCGCGCGGTGAGTGA