Detailed information of TA system TA080626

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1392103..1392669
• Replicon: chromosome
• Accession: NZ_CP023198
• Organism: Bifidobacterium breve strain DRBB29

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DRBB29_RS06550
• Protein ID: WP_106621704.1
• Coordinates: 1392376..1392669 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S2VZL2
• Locus tag: DRBB29_RS06545
• Protein ID: WP_071477905.1
• Coordinates: 1392103..1392372 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DRBB29_RS06520	1387852..1388547	-	696	WP_003829410.1	response regulator transcription factor	-
DRBB29_RS06525	1388673..1389188	+	516	WP_065452570.1	hypothetical protein	-
DRBB29_RS06530	1389185..1390075	+	891	WP_003831809.1	hypothetical protein	-
DRBB29_RS06535	1390072..1390752	+	681	WP_003829413.1	ABC transporter ATP-binding protein	-
DRBB29_RS06540	1390749..1391918	+	1170	WP_051994493.1	ABC transporter permease	-
DRBB29_RS06545	1392103..1392372	+	270	WP_071477905.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DRBB29_RS06550	1392376..1392669	+	294	WP_106621704.1	type II toxin-antitoxin system YafQ family toxin	Toxin
DRBB29_RS06555	1392777..1393073	+	297	WP_106622093.1	transporter	-
DRBB29_RS06560	1393402..1394982	+	1581	WP_106621705.1	amino acid permease	-
DRBB29_RS06565	1395224..1395463	-	240	WP_014483708.1	hypothetical protein	-
DRBB29_RS06570	1395761..1396114	+	354	WP_014483707.1	DUF488 domain-containing protein	-
DRBB29_RS11500	1396180..1396608	-	429	WP_186278293.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1373395..1393073	19678

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-95)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-88)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11132.85 Da
• Isoelectric Point: 9.7881

>T80626 WP_106621704.1 NZ_CP023198:1392376-1392669 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEAIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Nucleotide

• Length: 294 bp

>T80626 NZ_CP023198:1392376-1392669 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACGGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAACACGCTGATTTACGCCCGCT
GAAAGAAGCCATTCGTCTGGTGCTTGAGGACACGGCGGACTCCAAGGAAGCATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATCTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTTATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9888.18 Da
• Isoelectric Point: 4.7872

>AT80626 WP_071477905.1 NZ_CP023198:1392103-1392372 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGRPRFNSA
DEMFDSLGI

Nucleotide

• Length: 270 bp

>AT80626 NZ_CP023198:1392103-1392372 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAACAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCCCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCGACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S2VZL2