Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1267636..1268202 Replicon chromosome
Accession NZ_CP023193
Organism Bifidobacterium breve strain NRBB18

Toxin (Protein)


Gene name relE Uniprot ID S2ZEY8
Locus tag NRBB18_RS05660 Protein ID WP_014483710.1
Coordinates 1267909..1268202 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag NRBB18_RS05655 Protein ID WP_014483711.1
Coordinates 1267636..1267905 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRBB18_RS05630 1263377..1264072 - 696 WP_052790767.1 response regulator transcription factor -
NRBB18_RS05635 1264198..1264713 + 516 WP_013140733.1 hypothetical protein -
NRBB18_RS05640 1264710..1265600 + 891 WP_007056280.1 hypothetical protein -
NRBB18_RS05645 1265597..1266285 + 689 Protein_1050 ABC transporter ATP-binding protein -
NRBB18_RS05650 1266282..1267451 + 1170 WP_106622626.1 ABC transporter permease -
NRBB18_RS05655 1267636..1267905 + 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NRBB18_RS05660 1267909..1268202 + 294 WP_014483710.1 type II toxin-antitoxin system YafQ family toxin Toxin
NRBB18_RS05670 1268871..1269422 + 552 WP_015438834.1 RNA polymerase sigma factor -
NRBB18_RS05675 1269456..1270283 + 828 WP_015438835.1 hypothetical protein -
NRBB18_RS05680 1270415..1271042 + 628 Protein_1056 hypothetical protein -
NRBB18_RS05685 1271039..1271821 + 783 WP_021649673.1 hypothetical protein -
NRBB18_RS05690 1271874..1272749 + 876 WP_021649674.1 ABC transporter ATP-binding protein -
NRBB18_RS05695 1272803..1273201 + 399 WP_016462921.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1259955..1279929 19974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.96 Da        Isoelectric Point: 9.7881

>T80616 WP_014483710.1 NZ_CP023193:1267909-1268202 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T80616 NZ_CP023193:1267909-1268202 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT80616 WP_014483711.1 NZ_CP023193:1267636-1267905 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT80616 NZ_CP023193:1267636-1267905 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S2ZEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References