Detailed information of TA system TA080607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2060703..2061286
• Replicon: chromosome
• Accession: NZ_CP023189
• Organism: Acetobacter pomorum strain SH

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: F1YT37
• Locus tag: CJF59_RS09755
• Protein ID: WP_006116155.1
• Coordinates: 2061032..2061286 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CJF59_RS09750
• Protein ID: WP_089178780.1
• Coordinates: 2060703..2061035 (-)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJF59_RS09730	2056469..2057719	+	1251	WP_012812328.1	IS701-like element IS1452 family transposase	-
CJF59_RS09735	2057912..2058675	+	764	WP_089179917.1	IS5 family transposase	-
CJF59_RS09740	2058734..2059984	+	1251	WP_012812328.1	IS701-like element IS1452 family transposase	-
CJF59_RS09745	2059988..2060395	+	408	WP_205413833.1	terminase small subunit	-
CJF59_RS09750	2060703..2061035	-	333	WP_089178780.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CJF59_RS09755	2061032..2061286	-	255	WP_006116155.1	type II toxin-antitoxin system HicA family toxin	Toxin
CJF59_RS09760	2061526..2062726	-	1201	Protein_1874	tyrosine-type recombinase/integrase	-
CJF59_RS09765	2063070..2064665	+	1596	WP_089178779.1	restriction endonuclease	-
CJF59_RS09770	2065025..2065366	+	342	WP_089179899.1	hypothetical protein	-
CJF59_RS09775	2065765..2066106	-	342	WP_089178778.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (56-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9479.92 Da
• Isoelectric Point: 10.3861

>T80607 WP_006116155.1 NZ_CP023189:c2061286-2061032 [Acetobacter pomorum]
MKAKHRRTLELIFKRPVSGNVPWADIEALFVSLGAEVSEREGSRIGVFLFDEVKVFHRPHPKPDTDKGAVASVRKWLEQN
GVTP

Nucleotide

• Length: 255 bp

>T80607 NZ_CP023189:c2061286-2061032 [Acetobacter pomorum]
ATGAAAGCCAAGCACCGCCGCACATTGGAACTGATTTTCAAGCGTCCTGTTTCGGGCAATGTGCCATGGGCAGACATTGA
AGCTTTATTTGTTTCCCTAGGGGCGGAGGTGTCTGAAAGAGAAGGCTCCCGCATAGGGGTGTTCCTGTTTGATGAGGTAA
AGGTGTTTCATAGACCTCACCCCAAACCGGATACAGACAAGGGTGCTGTAGCCTCTGTAAGAAAATGGCTTGAGCAGAAT
GGAGTGACGCCATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12020.69 Da
• Isoelectric Point: 4.6742

>AT80607 WP_089178780.1 NZ_CP023189:c2061035-2060703 [Acetobacter pomorum]
MNNVMEIGGHRAVIQFDPEIGMFRGEFLGLNGGADFYADSVAGLQQEGETSLRVFMEMCAEKGIDPVKHYSGRFVVRLPE
DVHARVAEIAAARGISLNRLVQDVLAQVEG

Nucleotide

• Length: 333 bp

>AT80607 NZ_CP023189:c2061035-2060703 [Acetobacter pomorum]
ATGAACAACGTAATGGAAATTGGCGGCCATCGGGCTGTTATTCAGTTTGATCCTGAAATCGGGATGTTCCGGGGTGAGTT
TCTGGGGCTGAACGGAGGGGCTGATTTCTACGCAGATAGTGTGGCAGGCCTTCAGCAGGAAGGGGAAACTTCCCTCCGTG
TCTTCATGGAGATGTGTGCTGAGAAAGGCATTGATCCCGTGAAGCATTATTCAGGCCGGTTTGTTGTGAGGCTACCAGAA
GACGTTCATGCACGGGTAGCTGAGATTGCTGCAGCACGCGGGATCAGTCTTAACCGACTGGTGCAGGATGTTTTGGCACA
GGTTGAAGGATAA

Structures

Toxin

• AlphaFold DB: A0A401X5W6