Detailed information of TA system TA080590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-ArgA
• Location: 1408744..1409563
• Replicon: chromosome
• Accession: NZ_CP023185
• Organism: Klebsiella michiganensis strain K518

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: CKQ55_RS07145
• Protein ID: WP_004110819.1
• Coordinates: 1409306..1409563 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: CKQ55_RS07140
• Protein ID: WP_014837489.1
• Coordinates: 1408744..1409295 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CKQ55_RS07120	1404668..1405441	+	774	WP_088168442.1	Zygote formation protein zyg1	-
CKQ55_RS07125	1405752..1406225	+	474	WP_032693194.1	hypothetical protein	-
CKQ55_RS07130	1406494..1406909	-	416	Protein_1341	type II toxin-antitoxin system VapC family toxin	-
CKQ55_RS32180	1406906..1407064	-	159	Protein_1342	hypothetical protein	-
CKQ55_RS07135	1407098..1408726	-	1629	WP_014837490.1	SAM-dependent methyltransferase	-
CKQ55_RS07140	1408744..1409295	-	552	WP_014837489.1	N-acetyltransferase	Antitoxin
CKQ55_RS07145	1409306..1409563	-	258	WP_004110819.1	YjhX family toxin	Toxin
CKQ55_RS07150	1410239..1411423	+	1185	WP_014228054.1	mannonate dehydratase	-
CKQ55_RS07155	1411497..1412972	+	1476	WP_014228053.1	fructuronate reductase	-
CKQ55_RS07160	1413111..1413887	+	777	WP_004847986.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (22-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T80590 WP_004110819.1 NZ_CP023185:c1409563-1409306 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T80590 NZ_CP023185:c1409563-1409306 [Klebsiella michiganensis]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCTTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19902.64 Da
• Isoelectric Point: 6.4913

>AT80590 WP_014837489.1 NZ_CP023185:c1409295-1408744 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT80590 NZ_CP023185:c1409295-1408744 [Klebsiella michiganensis]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGGCGGTATTTGTTCTGGGCCACGCCGCTTACTACCCCAGGCACGGGTTTGAGCCAGGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2