80589

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1166176..1166795 Replicon chromosome
Accession NZ_CP023185
Organism Klebsiella michiganensis strain K518

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag CKQ55_RS05970 Protein ID WP_004099646.1
Coordinates 1166577..1166795 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag CKQ55_RS05965 Protein ID WP_004129911.1
Coordinates 1166176..1166550 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKQ55_RS05955 1161334..1162527 + 1194 WP_004136054.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CKQ55_RS05960 1162550..1165696 + 3147 WP_014228207.1 multidrug efflux RND transporter permease subunit -
CKQ55_RS05965 1166176..1166550 + 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
CKQ55_RS05970 1166577..1166795 + 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
CKQ55_RS05975 1166958..1167524 + 567 WP_014837607.1 maltose O-acetyltransferase -
CKQ55_RS05980 1167651..1168121 + 471 WP_014228205.1 YlaC family protein -
CKQ55_RS05985 1168096..1169550 - 1455 WP_014837606.1 PLP-dependent aminotransferase family protein -
CKQ55_RS05990 1169652..1170350 + 699 WP_014228203.1 GNAT family N-acetyltransferase -
CKQ55_RS05995 1170347..1170487 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
CKQ55_RS06000 1170487..1170750 - 264 WP_004848323.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T80589 WP_004099646.1 NZ_CP023185:1166577-1166795 [Klebsiella michiganensis]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T80589 NZ_CP023185:1166577-1166795 [Klebsiella michiganensis]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCTGCGGCCGATCATCGTCTTGCAGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT80589 WP_004129911.1 NZ_CP023185:1166176-1166550 [Klebsiella michiganensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT80589 NZ_CP023185:1166176-1166550 [Klebsiella michiganensis]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGATCCAACCTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTTGCACTTAATTATAAAATTAAGTACGCAGAGGATAATAAGCTGATTACCCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGCGCAGATCTGCAGAAATGGCGTAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References