Detailed information of TA system TA080588

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3157585..3158254
• Replicon: chromosome
• Accession: NZ_CP023184
• Organism: Yersinia ruckeri strain NHV_3758

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A380QS17
• Locus tag: CLC90_RS14545
• Protein ID: WP_038241020.1
• Coordinates: 3157585..3158007 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: CLC90_RS14550
• Protein ID: WP_004719196.1
• Coordinates: 3157988..3158254 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CLC90_RS14525	3153424..3155157	-	1734	WP_038276198.1	single-stranded-DNA-specific exonuclease RecJ	-
CLC90_RS14530	3155164..3155880	-	717	WP_004719192.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
CLC90_RS14535	3155912..3156811	-	900	WP_004719193.1	site-specific tyrosine recombinase XerD	-
CLC90_RS14540	3156919..3157437	+	519	WP_038241022.1	flavodoxin FldB	-
CLC90_RS14545	3157585..3158007	-	423	WP_038241020.1	protein YgfX	Toxin
CLC90_RS14550	3157988..3158254	-	267	WP_004719196.1	FAD assembly factor SdhE	Antitoxin
CLC90_RS14555	3158548..3159540	+	993	WP_096823598.1	tRNA-modifying protein YgfZ	-
CLC90_RS14560	3159679..3160344	-	666	WP_175537887.1	hemolysin III family protein	-
CLC90_RS14565	3160661..3161061	+	401	Protein_2801	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16451.41 Da
• Isoelectric Point: 11.1478

>T80588 WP_038241020.1 NZ_CP023184:c3158007-3157585 [Yersinia ruckeri]
VAQWRCDLRVSWRTQLFSLLVHGVLVLLTLVVPWPDGFTPLWLILLTLVVFECIRSQKNITSRQGEIRLKAGNLLIWKWQ
EWTLVRPPWITRYGVLLSLQGAGSRRRKRIWLASDSMSEEKWRELCLILRHTFDSAAGRE

Nucleotide

• Length: 423 bp

>T80588 NZ_CP023184:c3158007-3157585 [Yersinia ruckeri]
GTGGCCCAGTGGCGATGTGATCTGCGGGTTTCATGGCGCACCCAACTTTTCTCACTATTGGTACACGGTGTTCTGGTATT
ACTGACACTGGTGGTACCTTGGCCTGACGGATTTACTCCGCTATGGCTTATATTGCTGACGCTGGTGGTGTTTGAATGCA
TTCGCAGCCAGAAGAACATTACCTCTCGACAGGGAGAGATCCGGCTTAAAGCGGGAAATCTGTTGATTTGGAAGTGGCAA
GAGTGGACGTTGGTGCGGCCGCCGTGGATTACCCGCTACGGCGTATTATTATCGTTACAAGGCGCTGGCAGCCGCCGCCG
AAAACGTATTTGGCTAGCCTCCGACAGCATGTCGGAAGAAAAATGGCGCGAGTTGTGTCTGATATTACGACATACTTTTG
ATTCTGCGGCAGGCCGTGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10532.09 Da
• Isoelectric Point: 6.7185

>AT80588 WP_004719196.1 NZ_CP023184:c3158254-3157988 [Yersinia ruckeri]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDTLNDNDKRVFIRLLTSDDPDLFNWLMNHGEPQDSELKRMVKLIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT80588 NZ_CP023184:c3158254-3157988 [Yersinia ruckeri]
ATGGAAATTGATAACAAAGCCCGAATCCATTGGGCATGCCGCCGGGGTATGCGTGAACTGGATATCTCCATAATGCCATT
TTTCGAACATGAATATGACACGCTAAACGATAATGATAAGCGCGTATTTATCCGCTTGCTGACGAGTGATGATCCTGATT
TATTCAATTGGTTGATGAACCACGGCGAGCCGCAGGATAGCGAACTGAAACGAATGGTTAAACTGATTCAGACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A380QS17