Detailed information of TA system TA080578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2028181..2029099
• Replicon: chromosome
• Accession: NZ_CP023184
• Organism: Yersinia ruckeri strain NHV_3758

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: CLC90_RS09190
• Protein ID: WP_038242633.1
• Coordinates: 2028641..2029099 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A085U7R3
• Locus tag: CLC90_RS09185
• Protein ID: WP_038242631.1
• Coordinates: 2028181..2028627 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CLC90_RS09165	2023879..2024583	+	705	WP_004717543.1	murein tripeptide amidase MpaA	-
CLC90_RS09170	2024594..2025568	-	975	WP_071706618.1	L-Ala-D/L-Glu epimerase	-
CLC90_RS09175	2025718..2026221	+	504	WP_004717547.1	thiol peroxidase	-
CLC90_RS09180	2026256..2027863	-	1608	WP_096823414.1	transcriptional regulator TyrR	-
CLC90_RS09185	2028181..2028627	+	447	WP_038242631.1	DUF2384 domain-containing protein	Antitoxin
CLC90_RS09190	2028641..2029099	+	459	WP_038242633.1	RES domain-containing protein	Toxin
CLC90_RS09195	2029103..2030161	-	1059	WP_038242635.1	YcjF family protein	-
CLC90_RS09200	2030158..2031555	-	1398	WP_004717556.1	YcjX family protein	-
CLC90_RS09205	2031536..2031778	-	243	WP_096823415.1	phage shock protein PspD	-
CLC90_RS09210	2031842..2032201	-	360	WP_004717559.1	envelope stress response membrane protein PspC	-
CLC90_RS09215	2032201..2032428	-	228	WP_038242637.1	envelope stress response membrane protein PspB	-
CLC90_RS09220	2032512..2033177	-	666	WP_038275968.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17072.55 Da
• Isoelectric Point: 6.6384

>T80578 WP_038242633.1 NZ_CP023184:2028641-2029099 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSVSSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Nucleotide

• Length: 459 bp

>T80578 NZ_CP023184:2028641-2029099 [Yersinia ruckeri]
GTGATGCTCTACCGGATAGTTCACAACCGTTACCTGGCAACGGCCTGGACCGGATATGGCGCAGAAACCTATGGTGGCCG
CTGGAATCATAAAGGCCATGCGGCGATTTATCTGGCCAGTAGCGTTTCTCTGGCGATGCTCGAAACACTGGTGCATGTAG
AAGATAGCGCGACGCTGAACGATTTTAATCTATTTCAGATAACCATTCCCGATAATGCAATTATGGTACTGCAACAGCAA
GATTGGCCACGTGGATGGCGAGATGACCCCACCCCCGTGGCCACCATGGACATCGGCACCGAATGGATTGGTTCAGTATC
ATCTGTCGGTCTGCTGGTACCATCCACGTTAGTCCCTTTGGAAAGAAATATGCTGGTGAATCCTAAACACCGCGATTTCG
CCTCGTGCCTGAAAAGCATCAATCCACTGACGTTCAGTTTTGATCCTCGTCTAAAGTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16406.87 Da
• Isoelectric Point: 8.0956

>AT80578 WP_038242631.1 NZ_CP023184:2028181-2028627 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT80578 NZ_CP023184:2028181-2028627 [Yersinia ruckeri]
ATGAGAACTTATCACCCAAGCCCGATGGCCAAAGTCAGCGCACTATGGCGTGAGATTGGTCTACCCGCCAGTCGTGGCAC
CGCTTTGGTGGACAGCATAAAACTGGGATTTACTGTGGATGTGATCGACACTATACATTTATGGGCTGATATGCCTAAAT
CTGAAATATTACGCGCTACGGGCATTCCGAGCCGCAGTCTGACGCGCCGTCGTACCCATGATGGGCGTTTTACCCCGGAA
GAAAGCGAACGTATTGCACGGTTTGTCCGGGTTATGGATGCGGCGGTAGATTTGTTCGGTGGTGACCGCACCAAAGCAAC
CGCATGGATGTCGATGCCGGTCAAAGGGCTGGGTAATCGAACGCCCGATTCACTGCTGGAAACCGAAACCGGTGCGTTGG
AAATCTGCGACCTGATTGGTCGTCTCGAACATGGGGTCTTTTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A085U7R3