Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1104803..1105426 Replicon chromosome
Accession NZ_CP023184
Organism Yersinia ruckeri strain NHV_3758

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag CLC90_RS05090 Protein ID WP_038243726.1
Coordinates 1104803..1105006 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag CLC90_RS05095 Protein ID WP_004718732.1
Coordinates 1105058..1105426 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLC90_RS05065 1100658..1100996 + 339 WP_007886947.1 P-II family nitrogen regulator -
CLC90_RS05070 1101035..1102324 + 1290 WP_004718723.1 ammonium transporter AmtB -
CLC90_RS05075 1102439..1103302 - 864 WP_004718726.1 acyl-CoA thioesterase II -
CLC90_RS05080 1103680..1103994 - 315 WP_004718728.1 MGMT family protein -
CLC90_RS05090 1104803..1105006 - 204 WP_038243726.1 expression modulating protein YmoA Toxin
CLC90_RS05095 1105058..1105426 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
CLC90_RS17665 1106475..1106636 + 162 WP_004718735.1 hypothetical protein -
CLC90_RS05105 1106755..1106898 - 144 WP_004718738.1 type B 50S ribosomal protein L36 -
CLC90_RS05110 1106918..1107172 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T80577 WP_038243726.1 NZ_CP023184:c1105006-1104803 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

>T80577 NZ_CP023184:c1105006-1104803 [Yersinia ruckeri]
ATGACCAAAACTGACTACCTAATGCGTTTAAGAAAATGCACAACAATTGACACACTAGAGCGTGTTATTGAAAAAAATAA
GTATGAGCTATCTGATGATGAACTAGAATTATTCTATTCTGCTGCGGATCATCGTCTAGCTGAACTTACCATGAATAAGT
TATACGATAAAATTCCTGCAACTGTCTGGCAACATGTGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT80577 WP_004718732.1 NZ_CP023184:c1105426-1105058 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp

>AT80577 NZ_CP023184:c1105426-1105058 [Yersinia ruckeri]
ATGGATGAGTACTCACCTAAGCGACATGATATTGCTCAGTTGAAATTCTTATGTGAGAATTTGTATGATGAAGGTATCGC
CACATTGGGCGATAGCCACCACGGCTGGGTTAATGATCCAACCTCCGCGGTAAATCTCCAACTGAATGATTTAATCGAAC
ACATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACGCAGACGAAATCGATCTCTGCGAGTTGGTGGAGGAATATCTA
GACGATACATATACCTTGTTCAGCAGTTACGGAATCAATGATCCTGATTTACGCCGCTGGCAGAAAACAAAAGACCGATT
ATTCAGACTATTTTCAGGGGAATACCTATGTGCCCTGATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References