Detailed information of TA system TA080575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 605892..606426
• Replicon: chromosome
• Accession: NZ_CP023184
• Organism: Yersinia ruckeri strain NHV_3758

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CLC90_RS02805
• Protein ID: WP_071666901.1
• Coordinates: 606136..606426 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A1JJ37
• Locus tag: CLC90_RS02800
• Protein ID: WP_005175264.1
• Coordinates: 605892..606146 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CLC90_RS02790	603000..603944	-	945	WP_038275265.1	hypothetical protein	-
CLC90_RS02795	604459..605718	+	1260	Protein_533	integrase arm-type DNA-binding domain-containing protein	-
CLC90_RS02800	605892..606146	+	255	WP_005175264.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CLC90_RS02805	606136..606426	+	291	WP_071666901.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CLC90_RS02810	606690..607079	+	390	WP_096823270.1	restriction endonuclease subunit S	-
CLC90_RS02815	607203..607778	+	576	WP_071706520.1	DUF4433 domain-containing protein	-
CLC90_RS02820	607781..608437	+	657	WP_096823271.1	DUF4433 domain-containing protein	-
CLC90_RS02825	608434..609501	+	1068	WP_096823272.1	macro domain-containing protein	-
CLC90_RS02830	609522..609788	+	267	Protein_540	hypothetical protein	-
CLC90_RS02835	609863..610060	+	198	WP_096823273.1	transposase	-
CLC90_RS02840	610000..610497	+	498	Protein_542	IS30-like element ISYkr1 family transposase	-
CLC90_RS02845	610503..611196	+	694	Protein_543	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	596329..614583	18254

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11421.37 Da
• Isoelectric Point: 9.9816

>T80575 WP_071666901.1 NZ_CP023184:606136-606426 [Yersinia ruckeri]
MTFNIDFDERALKEWHKLDKTIREQFKKKLRKLQENPYIESARLHGDLAGCFKIKLRASGFRLIYQVIDEEIVILIVAVG
KREDEKAYDLAKKRIQ

Nucleotide

• Length: 291 bp

>T80575 NZ_CP023184:606136-606426 [Yersinia ruckeri]
ATGACCTTTAATATCGACTTTGACGAACGGGCATTAAAAGAATGGCACAAACTAGATAAAACTATCCGAGAGCAATTTAA
AAAGAAACTAAGAAAATTACAGGAAAATCCCTATATTGAGTCAGCACGTTTGCACGGTGATCTGGCTGGTTGTTTCAAAA
TAAAATTACGCGCATCTGGCTTTCGGTTGATTTACCAAGTTATCGATGAGGAGATTGTGATTTTGATCGTTGCTGTTGGT
AAACGGGAAGATGAAAAAGCTTATGATCTTGCCAAGAAGCGAATCCAATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9680.07 Da
• Isoelectric Point: 4.8283

>AT80575 WP_005175264.1 NZ_CP023184:605892-606146 [Yersinia ruckeri]
MSTIQIRVDDELKKSAYQAFEKLNLSPSDALRLFLRYVAENEKLPFSEVSVMVSNQDEDADILAVVRERLKNPAKRIRVN
IDDL

Nucleotide

• Length: 255 bp

>AT80575 NZ_CP023184:605892-606146 [Yersinia ruckeri]
ATGAGTACTATCCAAATTCGTGTGGATGATGAACTGAAGAAAAGTGCATATCAGGCGTTTGAAAAACTGAATCTTTCGCC
TTCTGATGCACTACGCCTGTTCCTACGTTATGTTGCAGAGAACGAAAAGCTGCCTTTTTCAGAAGTATCCGTCATGGTCA
GTAATCAAGATGAGGATGCTGATATTTTGGCTGTTGTCCGTGAACGTTTGAAAAATCCTGCAAAGCGTATCAGAGTAAAT
ATTGATGACCTTTAA

Structures

Antitoxin

• AlphaFold DB: A1JJ37