Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 15890..16431 Replicon plasmid unnamed2
Accession NZ_CP023161
Organism Xanthomonas citri pv. malvacearum strain MS14003

Toxin (Protein)


Gene name mazF Uniprot ID A0A220WPB1
Locus tag CIW72_RS22885 Protein ID WP_005917856.1
Coordinates 16108..16431 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A220WPJ3
Locus tag CIW72_RS22880 Protein ID WP_005917854.1
Coordinates 15890..16111 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIW72_RS22835 11019..11333 - 315 WP_005918227.1 hypothetical protein -
CIW72_RS22840 11478..11801 - 324 WP_005918229.1 hypothetical protein -
CIW72_RS22845 11798..12424 - 627 WP_005918230.1 ParA family protein -
CIW72_RS23850 12593..12730 + 138 WP_005918231.1 hypothetical protein -
CIW72_RS22855 13143..13520 - 378 Protein_13 hypothetical protein -
CIW72_RS22865 14759..15022 - 264 WP_005917846.1 hypothetical protein -
CIW72_RS22870 15047..15448 - 402 WP_005917849.1 type II toxin-antitoxin system VapC family toxin -
CIW72_RS22875 15445..15705 - 261 WP_005917852.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CIW72_RS22880 15890..16111 + 222 WP_005917854.1 antitoxin MazE family protein Antitoxin
CIW72_RS22885 16108..16431 + 324 WP_005917856.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CIW72_RS22890 16457..16744 + 288 WP_029220894.1 hypothetical protein -
CIW72_RS22895 16751..17938 + 1188 WP_005917859.1 zeta toxin family protein -
CIW72_RS22900 18124..18408 - 285 WP_003490829.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..47414 47414


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11513.56 Da        Isoelectric Point: 6.2913

>T80540 WP_005917856.1 NZ_CP023161:16108-16431 [Xanthomonas citri pv. malvacearum]
MTQRGDLVTVALPGAYGKPRPALVIQSDLLAELESVLVCPITSDLRDAMFRVTVEPSLTNGLQKISQVMVDKTAPIPRAK
VSEPIGTLDAERMRAVERALMLVTGLA

Download         Length: 324 bp

>T80540 NZ_CP023161:16108-16431 [Xanthomonas citri pv. malvacearum]
ATGACGCAGCGTGGCGACTTGGTAACGGTGGCTTTGCCGGGAGCCTACGGCAAGCCACGGCCGGCGCTAGTCATCCAGTC
CGATTTGCTTGCCGAGCTGGAAAGCGTCCTCGTATGCCCGATCACAAGCGATCTGCGCGACGCGATGTTTCGGGTCACGG
TCGAGCCGAGTCTGACCAATGGTCTACAGAAGATTTCGCAGGTCATGGTGGACAAGACAGCACCGATACCTCGCGCGAAA
GTCAGTGAGCCGATTGGCACGCTCGACGCAGAACGCATGAGGGCCGTCGAACGCGCCCTCATGCTCGTCACCGGGCTGGC
ATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8240.23 Da        Isoelectric Point: 8.1023

>AT80540 WP_005917854.1 NZ_CP023161:15890-16111 [Xanthomonas citri pv. malvacearum]
MPRTHNPTNKVTRHRDRLRAAGYRPVQFWVHDTRSPELAAMLSRQCRSLHGDPTETDAIGFGEAAAGLIEGWE

Download         Length: 222 bp

>AT80540 NZ_CP023161:15890-16111 [Xanthomonas citri pv. malvacearum]
ATGCCGAGAACTCACAATCCGACGAACAAGGTCACCCGTCATCGTGACCGACTGCGTGCAGCCGGGTACAGGCCAGTGCA
GTTTTGGGTGCACGATACCCGCTCGCCCGAGTTGGCTGCGATGCTCAGCCGCCAGTGTCGCAGCCTGCATGGTGATCCAA
CCGAAACCGATGCTATCGGCTTCGGTGAAGCCGCCGCTGGCCTTATCGAGGGGTGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A220WPB1

Antitoxin

Source ID Structure
AlphaFold DB A0A220WPJ3

References