Detailed information of TA system TA080539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 15047..15705
• Replicon: plasmid unnamed2
• Accession: NZ_CP023161
• Organism: Xanthomonas citri pv. malvacearum strain MS14003

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CIW72_RS22870
• Protein ID: WP_005917849.1
• Coordinates: 15047..15448 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q3C002
• Locus tag: CIW72_RS22875
• Protein ID: WP_005917852.1
• Coordinates: 15445..15705 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIW72_RS22835	11019..11333	-	315	WP_005918227.1	hypothetical protein	-
CIW72_RS22840	11478..11801	-	324	WP_005918229.1	hypothetical protein	-
CIW72_RS22845	11798..12424	-	627	WP_005918230.1	ParA family protein	-
CIW72_RS23850	12593..12730	+	138	WP_005918231.1	hypothetical protein	-
CIW72_RS22855	13143..13520	-	378	Protein_13	hypothetical protein	-
CIW72_RS22865	14759..15022	-	264	WP_005917846.1	hypothetical protein	-
CIW72_RS22870	15047..15448	-	402	WP_005917849.1	type II toxin-antitoxin system VapC family toxin	Toxin
CIW72_RS22875	15445..15705	-	261	WP_005917852.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CIW72_RS22880	15890..16111	+	222	WP_005917854.1	antitoxin MazE family protein	-
CIW72_RS22885	16108..16431	+	324	WP_005917856.1	type II toxin-antitoxin system PemK/MazF family toxin	-
CIW72_RS22890	16457..16744	+	288	WP_029220894.1	hypothetical protein	-
CIW72_RS22895	16751..17938	+	1188	WP_005917859.1	zeta toxin family protein	-
CIW72_RS22900	18124..18408	-	285	WP_003490829.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..47414	47414

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• SpoVT-AbrB domain (8-52)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14643.05 Da
• Isoelectric Point: 7.2785

>T80539 WP_005917849.1 NZ_CP023161:c15448-15047 [Xanthomonas citri pv. malvacearum]
MKRYMLDTNTVSHLVKSHPAVSRRVIEVPMTALCMSAITGGELMFGLAKVPDAKRLQQAVMELLRRVDVLPWDGAVMERY
GSVRADLEKQGKSLGSLDMLIAAHALETDSVLVTNDAAFSRVVGLTVEDWTRS

Nucleotide

• Length: 402 bp

>T80539 NZ_CP023161:c15448-15047 [Xanthomonas citri pv. malvacearum]
ATGAAGCGGTACATGCTTGATACCAACACCGTGAGCCATCTCGTCAAGAGCCATCCGGCTGTCTCTCGACGGGTCATTGA
AGTGCCTATGACTGCGCTATGTATGTCCGCAATTACCGGTGGGGAGCTGATGTTCGGCTTGGCTAAGGTGCCAGACGCCA
AACGCCTTCAGCAAGCCGTCATGGAACTCCTGCGGCGCGTGGATGTGCTGCCTTGGGATGGCGCGGTAATGGAGCGTTAC
GGAAGCGTGAGAGCGGACCTAGAAAAGCAAGGTAAATCGCTTGGGTCGCTCGACATGCTTATCGCAGCACATGCACTGGA
AACGGATTCTGTCCTCGTTACCAATGACGCCGCATTTAGTCGTGTTGTTGGTTTGACCGTGGAAGATTGGACACGCAGCT
AA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9770.95 Da
• Isoelectric Point: 5.0941

>AT80539 WP_005917852.1 NZ_CP023161:c15705-15445 [Xanthomonas citri pv. malvacearum]
VSQVAKLFINGRSQAVRLPAAYRFTEKEVFIRQDPETGDVILSRKPATWEDFFIALKSADVPANFLDAAERNQGTQDRDP
FAGWRE

Nucleotide

• Length: 261 bp

>AT80539 NZ_CP023161:c15705-15445 [Xanthomonas citri pv. malvacearum]
GTGAGCCAAGTTGCCAAGCTGTTCATCAATGGCCGCAGCCAGGCAGTCCGCTTGCCTGCCGCCTATCGCTTTACCGAGAA
AGAGGTTTTCATTCGCCAAGACCCGGAGACCGGTGACGTCATCCTGTCTCGGAAGCCTGCAACGTGGGAGGACTTCTTTA
TCGCACTCAAGAGCGCAGATGTGCCTGCTAATTTTCTAGATGCCGCCGAGCGCAATCAGGGCACGCAGGACCGTGATCCT
TTTGCGGGATGGCGCGAATGA

Structures

Antitoxin

• AlphaFold DB: Q3C002