Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4971883..4972550 Replicon chromosome
Accession NZ_CP023159
Organism Xanthomonas citri pv. malvacearum strain MS14003

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag CIW72_RS22285 Protein ID WP_005916679.1
Coordinates 4972134..4972550 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag CIW72_RS22280 Protein ID WP_005916676.1
Coordinates 4971883..4972137 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIW72_RS23525 4967989..4968198 + 210 WP_108350128.1 RNA 2'-phosphotransferase -
CIW72_RS22260 4968381..4969646 + 1266 WP_005916664.1 cardiolipin synthase B -
CIW72_RS22265 4969672..4970199 - 528 WP_005916668.1 hypothetical protein -
CIW72_RS22270 4970438..4970644 + 207 WP_003489327.1 hypothetical protein -
CIW72_RS22275 4970631..4971737 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
CIW72_RS22280 4971883..4972137 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
CIW72_RS22285 4972134..4972550 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
CIW72_RS22290 4972878..4973840 - 963 WP_005916682.1 IS1595 family transposase -
CIW72_RS23530 4973859..4974320 - 462 WP_125825520.1 hypothetical protein -
CIW72_RS22300 4975499..4975825 + 327 WP_005912355.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T80538 WP_005916679.1 NZ_CP023159:4972134-4972550 [Xanthomonas citri pv. malvacearum]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T80538 NZ_CP023159:4972134-4972550 [Xanthomonas citri pv. malvacearum]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACGGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTGGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT80538 WP_005916676.1 NZ_CP023159:4971883-4972137 [Xanthomonas citri pv. malvacearum]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT80538 NZ_CP023159:4971883-4972137 [Xanthomonas citri pv. malvacearum]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References