Detailed information of TA system TA080531

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2277242..2277798
• Replicon: chromosome
• Accession: NZ_CP023155
• Organism: Xanthomonas citri pv. malvacearum strain AR81009

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CIW71_RS10100
• Protein ID: WP_033836591.1
• Coordinates: 2277508..2277798 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: CIW71_RS10095
• Protein ID: WP_004541313.1
• Coordinates: 2277242..2277520 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIW71_RS25155	2272781..2272948	-	168	WP_005913009.1	hypothetical protein	-
CIW71_RS25160	2274578..2274682	-	105	WP_196297133.1	DUF3387 domain-containing protein	-
CIW71_RS10080	2274645..2274860	-	216	Protein_1861	SAM-dependent DNA methyltransferase	-
CIW71_RS24795	2276596..2276757	+	162	WP_108350140.1	hypothetical protein	-
CIW71_RS25165	2276702..2277046	+	345	WP_198303413.1	hypothetical protein	-
CIW71_RS25170	2276949..2277161	+	213	WP_198303405.1	hypothetical protein	-
CIW71_RS10095	2277242..2277520	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
CIW71_RS10100	2277508..2277798	+	291	WP_033836591.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CIW71_RS10105	2277801..2278115	+	315	WP_015463310.1	hypothetical protein	-
CIW71_RS10110	2278386..2278565	+	180	WP_015463309.1	hypothetical protein	-
CIW71_RS10115	2278778..2279313	+	536	Protein_1870	transposase	-
CIW71_RS10120	2279425..2281236	-	1812	Protein_1871	TAL effector repeat-containing protein	-
CIW71_RS10125	2281287..2282512	+	1226	WP_087959283.1	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2271383..2299300	27917
	-	inside	IScluster/Tn	-	-	2273035..2285069	12034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10858.43 Da
• Isoelectric Point: 9.9308

>T80531 WP_033836591.1 NZ_CP023155:2277508-2277798 [Xanthomonas citri pv. malvacearum]
MPQVIFAPAAIGDMQRLREFLKPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRHAG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T80531 NZ_CP023155:2277508-2277798 [Xanthomonas citri pv. malvacearum]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCAACGGCTGCGCGAATTCCTGAAGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGTGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGTGGCTATGTGGCTCGGTACCGCCACGCTGGC
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT80531 WP_004541313.1 NZ_CP023155:2277242-2277520 [Xanthomonas citri pv. malvacearum]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT80531 NZ_CP023155:2277242-2277520 [Xanthomonas citri pv. malvacearum]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGTGAGGCGTTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACGGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACAGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0