Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 69727..70265 Replicon plasmid pFLAC0070_2
Accession NZ_CP023153
Organism Mycobacterium intracellulare subsp. chimaera strain FLAC0070

Toxin (Protein)


Gene name relE Uniprot ID D5P5D7
Locus tag CKJ58_RS26945 Protein ID WP_007172405.1
Coordinates 69727..69984 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M1FTM7
Locus tag CKJ58_RS26950 Protein ID WP_007172404.1
Coordinates 69981..70265 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKJ58_RS26920 65502..65714 - 213 WP_007172410.1 hypothetical protein -
CKJ58_RS26925 65833..66933 - 1101 WP_007172409.1 tyrosine-type recombinase/integrase -
CKJ58_RS26930 66923..67492 - 570 WP_007172408.1 hypothetical protein -
CKJ58_RS26935 68204..69202 + 999 WP_101930848.1 hypothetical protein -
CKJ58_RS26940 69219..69512 + 294 WP_007172406.1 hypothetical protein -
CKJ58_RS26945 69727..69984 - 258 WP_007172405.1 Txe/YoeB family addiction module toxin Toxin
CKJ58_RS26950 69981..70265 - 285 WP_007172404.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CKJ58_RS27345 70347..71108 - 762 WP_023363524.1 hypothetical protein -
CKJ58_RS26960 71111..71833 - 723 WP_139315444.1 ParA family protein -
CKJ58_RS26965 72497..73390 + 894 WP_052742716.1 DUF2637 domain-containing protein -
CKJ58_RS26970 73612..75132 + 1521 WP_007172379.1 DUF4226 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - esxN / eccA5 1..95687 95687


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10156.56 Da        Isoelectric Point: 9.8613

>T80524 WP_007172405.1 NZ_CP023153:c69984-69727 [Mycobacterium intracellulare subsp. chimaera]
VRSINFDPAAWEDFLFWLASDRKTARRITRLIAEIQRNPFAGIGKPEPLKGELSGYWSRRIDDEHRIVYRADDHEIKILK
ARYHY

Download         Length: 258 bp

>T80524 NZ_CP023153:c69984-69727 [Mycobacterium intracellulare subsp. chimaera]
GTGAGAAGCATCAACTTCGATCCCGCCGCGTGGGAGGACTTTCTATTTTGGCTGGCTTCCGACCGCAAAACAGCACGGCG
CATCACCAGACTCATCGCAGAAATCCAGCGCAACCCGTTTGCTGGGATTGGAAAACCAGAACCGCTCAAGGGTGAACTAT
CCGGGTACTGGTCGCGGCGCATCGACGACGAACACCGGATCGTCTACCGCGCAGATGATCACGAAATCAAGATCCTCAAA
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10455.62 Da        Isoelectric Point: 4.3885

>AT80524 WP_007172404.1 NZ_CP023153:c70265-69981 [Mycobacterium intracellulare subsp. chimaera]
MAISASEARQRLFPLLEQVNTDHEPVRITSKAGDAVLMSAADYDSWQETVYLLRSPENARRLMEAVARDNATRPTPGSYT
KSIDELEEMAGGQE

Download         Length: 285 bp

>AT80524 NZ_CP023153:c70265-69981 [Mycobacterium intracellulare subsp. chimaera]
ATGGCTATCAGTGCAAGTGAGGCCCGGCAGCGCCTCTTTCCGCTGCTTGAACAAGTCAACACCGACCACGAGCCTGTGCG
AATTACGTCCAAGGCCGGAGATGCAGTGCTCATGTCGGCCGCTGACTACGATTCGTGGCAAGAAACGGTCTACCTCCTGC
GTTCCCCCGAGAATGCCCGCCGACTCATGGAGGCCGTCGCCCGAGACAACGCCACCCGGCCCACCCCCGGCAGCTACACC
AAGTCGATCGACGAACTCGAGGAGATGGCCGGCGGCCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y0THX2

Antitoxin

Source ID Structure
AlphaFold DB M1FTM7

References