Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1554..2236 Replicon plasmid pFLAC0070_2
Accession NZ_CP023153
Organism Mycobacterium intracellulare subsp. chimaera strain FLAC0070

Toxin (Protein)


Gene name vapC Uniprot ID A0A854IDQ2
Locus tag CKJ58_RS26610 Protein ID WP_040624374.1
Coordinates 1554..1970 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5P579
Locus tag CKJ58_RS26615 Protein ID WP_007172349.1
Coordinates 1973..2236 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKJ58_RS26610 1554..1970 - 417 WP_040624374.1 type II toxin-antitoxin system VapC family toxin Toxin
CKJ58_RS26615 1973..2236 - 264 WP_007172349.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CKJ58_RS26620 2338..3312 + 975 WP_023363505.1 hypothetical protein -
CKJ58_RS26625 3376..4479 + 1104 WP_051404593.1 hypothetical protein -
CKJ58_RS26630 4934..5605 + 672 WP_141244939.1 C40 family peptidase -
CKJ58_RS26635 5719..7164 + 1446 WP_101930849.1 type VII secretion protein EccB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - esxN / eccA5 1..95687 95687
- flank IS/Tn - - 88..1272 1184


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14879.84 Da        Isoelectric Point: 5.4519

>T80523 WP_040624374.1 NZ_CP023153:c1970-1554 [Mycobacterium intracellulare subsp. chimaera]
MIIDSSAIVALIQGEDPYTEQIAAAIAADPSPVMSTANAAECLIVLTNRHGATARTVFDRLRSEINLGFQPFTLEHAIAA
HRAYLHYGKGRHPAALNYGDTMAYATAKLAHEPLIAIGNDFTQTDLEFNGVIGYWPAP

Download         Length: 417 bp

>T80523 NZ_CP023153:c1970-1554 [Mycobacterium intracellulare subsp. chimaera]
CTGATCATCGACTCTTCCGCGATCGTCGCCCTCATCCAGGGCGAGGACCCCTACACCGAACAGATCGCGGCCGCCATCGC
CGCCGATCCCAGCCCCGTCATGTCCACGGCCAACGCAGCCGAATGCCTCATCGTTCTCACCAACCGACACGGCGCGACCG
CGCGCACCGTCTTCGACCGCCTACGATCCGAAATCAACCTCGGCTTCCAGCCCTTCACCCTCGAACACGCGATCGCCGCC
CACCGCGCCTACCTCCACTACGGAAAAGGCCGCCACCCCGCCGCCCTCAACTACGGCGACACCATGGCCTACGCCACCGC
CAAACTCGCACACGAACCCCTCATCGCCATCGGCAACGACTTCACCCAAACCGACCTCGAATTCAACGGCGTCATCGGCT
ACTGGCCAGCGCCCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9884.20 Da        Isoelectric Point: 4.8359

>AT80523 WP_007172349.1 NZ_CP023153:c2236-1973 [Mycobacterium intracellulare subsp. chimaera]
MAFNVKDEEVIRFADELAARLHLPSRIDAIRYALRAQIEVTQSRTANRSAELLDVLKTEIWPLLDDRSPITKTEREQALG
YDTATGV

Download         Length: 264 bp

>AT80523 NZ_CP023153:c2236-1973 [Mycobacterium intracellulare subsp. chimaera]
ATGGCTTTCAACGTGAAAGACGAAGAGGTCATCCGCTTCGCAGACGAGCTCGCCGCGCGCCTCCACCTCCCCAGCCGCAT
CGACGCCATCCGCTACGCCCTGCGAGCCCAGATCGAAGTCACCCAATCCCGCACCGCAAACCGCTCCGCAGAACTGCTCG
ACGTCCTCAAAACCGAGATCTGGCCACTACTGGACGACCGATCCCCAATCACCAAAACCGAACGCGAACAAGCCCTCGGA
TACGACACAGCAACGGGAGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854IDQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y0TBQ2

References