Detailed information of TA system TA080517

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2550229..2551221
• Replicon: chromosome
• Accession: NZ_CP023149
• Organism: Mycobacterium intracellulare strain FLAC0181

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: CKJ67_RS12035
• Protein ID: WP_014382490.1
• Coordinates: 2550643..2551221 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: CKJ67_RS12030
• Protein ID: WP_014382489.1
• Coordinates: 2550229..2550618 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CKJ67_RS12005	2545783..2547786	+	2004	WP_095580067.1	phosphotransferase	-
CKJ67_RS12010	2547783..2548328	+	546	WP_051012195.1	gluconokinase	-
CKJ67_RS12015	2548352..2548927	-	576	WP_095580069.1	TetR/AcrR family transcriptional regulator	-
CKJ67_RS12020	2549052..2549855	+	804	WP_095580071.1	SAM-dependent methyltransferase	-
CKJ67_RS12025	2549895..2550170	+	276	WP_038536176.1	hypothetical protein	-
CKJ67_RS12030	2550229..2550618	+	390	WP_014382489.1	hypothetical protein	Antitoxin
CKJ67_RS12035	2550643..2551221	+	579	WP_014382490.1	zeta toxin family protein	Toxin
CKJ67_RS12040	2551241..2552308	-	1068	WP_014380064.1	DoxX family membrane protein	-
CKJ67_RS12045	2552404..2552964	+	561	WP_026071602.1	pyrazinamidase PncA	-
CKJ67_RS12050	2552964..2553764	+	801	WP_014382492.1	nuclear transport factor 2 family protein	-
CKJ67_RS12055	2553776..2554126	-	351	WP_020188920.1	DoxX family protein	-
CKJ67_RS12060	2554292..2555263	+	972	WP_014382494.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-137)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21077.18 Da
• Isoelectric Point: 11.0233

>T80517 WP_014382490.1 NZ_CP023149:2550643-2551221 [Mycobacterium intracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T80517 NZ_CP023149:2550643-2551221 [Mycobacterium intracellulare]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGTGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACAGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13498.86 Da
• Isoelectric Point: 5.1743

>AT80517 WP_014382489.1 NZ_CP023149:2550229-2550618 [Mycobacterium intracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIDESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT80517 NZ_CP023149:2550229-2550618 [Mycobacterium intracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGACGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA