Detailed information of TA system TA080514

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2397245..2398237
• Replicon: chromosome
• Accession: NZ_CP023147
• Organism: Mycobacterium marseillense strain FLAC0026

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A1A3JKZ4
• Locus tag: CKJ54_RS11215
• Protein ID: WP_067169891.1
• Coordinates: 2397659..2398237 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A1A3JJ40
• Locus tag: CKJ54_RS11210
• Protein ID: WP_067169894.1
• Coordinates: 2397245..2397634 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CKJ54_RS11190	2392376..2393056	-	681	WP_208620037.1	hypothetical protein	-
CKJ54_RS11195	2393136..2394653	+	1518	WP_067169904.1	carboxylesterase/lipase family protein	-
CKJ54_RS11200	2394672..2396684	+	2013	WP_067169901.1	phosphotransferase	-
CKJ54_RS11205	2396681..2397175	+	495	WP_067169898.1	gluconokinase	-
CKJ54_RS11210	2397245..2397634	+	390	WP_067169894.1	hypothetical protein	Antitoxin
CKJ54_RS11215	2397659..2398237	+	579	WP_067169891.1	zeta toxin family protein	Toxin
CKJ54_RS11220	2398314..2399381	-	1068	WP_067169888.1	DoxX family membrane protein	-
CKJ54_RS11225	2399477..2400037	+	561	WP_157746189.1	pyrazinamidase PncA	-
CKJ54_RS11230	2400037..2400837	+	801	WP_067169880.1	nuclear transport factor 2 family protein	-
CKJ54_RS11235	2400849..2401199	-	351	WP_067169877.1	DoxX family protein	-
CKJ54_RS11240	2401365..2402336	+	972	WP_067169873.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-140)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21125.21 Da
• Isoelectric Point: 11.0157

>T80514 WP_067169891.1 NZ_CP023147:2397659-2398237 [Mycobacterium marseillense]
MQRLDLVVGPNGAGKSTFIAFTLARLLPGSLVVNADEIARQRWPEEPAGHAYDAARIAAETRAKLIDLGRSLIAETVFSH
PSKLDLIHSARRAGFSVIVHALLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTEAVALADIATVYDNSRLRG
PRIVARLSGGMTVGRPDWPAWTPGTLGSRWTD

Nucleotide

• Length: 579 bp

>T80514 NZ_CP023147:2397659-2398237 [Mycobacterium marseillense]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCGACTGCT
GCCCGGCAGCCTGGTGGTCAACGCCGACGAAATCGCTAGGCAGCGCTGGCCGGAGGAGCCGGCGGGGCACGCCTACGACG
CAGCGCGAATCGCCGCCGAGACCCGCGCGAAGCTGATCGACCTGGGGCGGTCGCTCATCGCGGAGACCGTGTTCTCCCAC
CCGTCGAAGCTCGACCTCATCCACTCCGCCCGCCGCGCGGGCTTCAGCGTCATCGTGCACGCATTGCTCATCCCGGAAGA
CCTCGCCGTCGAACGTGTCCGGCACCGCGTGCGCGCCGGCGGCCATGACGTACCGGAAACCAAGGTCCGCGAGCGCCATC
GCCGCTTATGGACACCGGTCACCGAGGCCGTCGCGCTGGCCGACATCGCCACCGTCTACGACAACAGCCGCCTGCGCGGG
CCGCGCATCGTCGCCCGCCTCAGCGGCGGCATGACGGTCGGTCGCCCCGACTGGCCGGCGTGGACGCCAGGGACCCTGGG
GTCACGCTGGACGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13526.92 Da
• Isoelectric Point: 5.1725

>AT80514 WP_067169894.1 NZ_CP023147:2397245-2397634 [Mycobacterium marseillense]
MPDAPDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLPTGELTVEEGVVFNAEI
SAAIEESLAHTNYGATLAGQGVTTVALNDDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT80514 NZ_CP023147:2397245-2397634 [Mycobacterium marseillense]
ATGCCCGACGCTCCCGATCGCGTCACCCGGGTGGCGTCCGACCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGCCAGAG
CCGGTCGGCCAAGCAGCAACTCGACCACTGGGCGCGGGTCGGGCGGGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTTGAGGCCGCGCTCGCCGGCCAGCTGCCGACCGGCGAACTGACCGTCGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCCATCGAAGAAAGCCTGGCGCACACCAACTACGGGGCGACGCTGGCGGGGCAGGGAGTCACCACGGTCGCCCT
CAACGACGACGGCGACATCGTTGAGCACCGGCCCGACGGCGCCGCCGTGGTGCTGGCGCGCGGACGCTGA

Structures

Toxin

• AlphaFold DB: A0A1A3JKZ4

Antitoxin

• AlphaFold DB: A0A1A3JJ40