Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 875874..876527 Replicon chromosome
Accession NZ_CP023147
Organism Mycobacterium marseillense strain FLAC0026

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A1A3JRV9
Locus tag CKJ54_RS04475 Protein ID WP_067167921.1
Coordinates 876066..876527 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID A0A1A3JUV6
Locus tag CKJ54_RS04470 Protein ID WP_067167924.1
Coordinates 875874..876062 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKJ54_RS04460 871841..873424 + 1584 WP_095576578.1 serine hydrolase -
CKJ54_RS04465 873421..875808 + 2388 WP_095576579.1 cation-translocating P-type ATPase -
CKJ54_RS04470 875874..876062 + 189 WP_067167924.1 antitoxin Antitoxin
CKJ54_RS04475 876066..876527 + 462 WP_067167921.1 SRPBCC family protein Toxin
CKJ54_RS04480 876612..877381 + 770 Protein_877 VOC family protein -
CKJ54_RS04485 877456..877890 + 435 WP_083017984.1 hypothetical protein -
CKJ54_RS04490 877895..878383 - 489 WP_095576580.1 VOC family protein -
CKJ54_RS04495 878383..879897 - 1515 WP_095576581.1 carotenoid oxygenase family protein -
CKJ54_RS04500 879900..881120 - 1221 WP_095576582.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16724.22 Da        Isoelectric Point: 8.5214

>T80513 WP_067167921.1 NZ_CP023147:876066-876527 [Mycobacterium marseillense]
MAKLSGSIDVPLPPEVAWQYASDLSRYKDWLTIHRVWRSTLPDEIEKGSVVESIVEVKGMHNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKIQPNGDGSIVSFDVHLGGPALFGPIGMIVAAALRGDINQSLENFVTVFTRSDPSTNGHR

Download         Length: 462 bp

>T80513 NZ_CP023147:876066-876527 [Mycobacterium marseillense]
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCACCCGAGGTGGCCTGGCAGTACGCCTCCGATCTGTCCCGGTA
CAAGGATTGGCTGACCATCCACCGCGTGTGGCGCAGCACATTGCCCGACGAGATCGAAAAGGGCTCGGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCACAACCGGATCAAATGGACGGTCGTGCGTTATAAGCCCCCCGAGGGCATGACGCTCAAC
GGCGACGGCGTCGGCGGTGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAATGGGGACGGCTCCATCGTCAGCTTCGA
CGTGCACCTCGGCGGCCCCGCACTGTTCGGCCCCATCGGCATGATCGTCGCGGCGGCACTGCGCGGCGACATCAACCAGT
CGCTGGAGAACTTCGTCACGGTCTTCACCCGATCCGATCCGAGCACCAACGGGCATCGGTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6780.47 Da        Isoelectric Point: 4.4702

>AT80513 WP_067167924.1 NZ_CP023147:875874-876062 [Mycobacterium marseillense]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGPADPGDQQN

Download         Length: 189 bp

>AT80513 NZ_CP023147:875874-876062 [Mycobacterium marseillense]
ATGGGATTCCTGGACAAGGCCAAGGATCTGTTGTCGCAGAACGCCGACAAGGTCGAGATGGCCATCGACAAGGCCGGCGA
GTTCGTCGACGAGAAGACGCAGGGCAAATACTCCGACACCATCCACCAGGTGCAGGAGCAAGCGAAGAAGGCCACCGGGC
CCGCGGACCCGGGCGACCAGCAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A3JRV9

Antitoxin

Source ID Structure
AlphaFold DB A0A1A3JUV6

References