Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4746582..4747406 | Replicon | chromosome |
| Accession | NZ_CP023142 | ||
| Organism | Escherichia coli strain CFSAN061770 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A2U2VR48 |
| Locus tag | CA696_RS24830 | Protein ID | WP_053287712.1 |
| Coordinates | 4747029..4747406 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | CA696_RS24825 | Protein ID | WP_095454386.1 |
| Coordinates | 4746582..4746938 (+) | Length | 119 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CA696_RS24780 | 4741712..4742596 | + | 885 | WP_053287869.1 | 50S ribosome-binding GTPase | - |
| CA696_RS24785 | 4742715..4743392 | + | 678 | WP_001097362.1 | hypothetical protein | - |
| CA696_RS24790 | 4743398..4743631 | + | 234 | WP_053287870.1 | DUF905 family protein | - |
| CA696_RS24800 | 4743733..4744551 | + | 819 | WP_053287871.1 | DUF945 domain-containing protein | - |
| CA696_RS24805 | 4744633..4745112 | + | 480 | WP_000860074.1 | antirestriction protein | - |
| CA696_RS24810 | 4745128..4745604 | + | 477 | WP_001366830.1 | RadC family protein | - |
| CA696_RS24815 | 4745667..4745888 | + | 222 | WP_095454389.1 | DUF987 domain-containing protein | - |
| CA696_RS24820 | 4746261..4746535 | + | 275 | Protein_4552 | antitoxin of the YeeV-YeeU toxin-antitoxin system | - |
| CA696_RS24825 | 4746582..4746938 | + | 357 | WP_095454386.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CA696_RS24830 | 4747029..4747406 | + | 378 | WP_053287712.1 | TA system toxin CbtA family protein | Toxin |
| CA696_RS24835 | 4747403..4747891 | + | 489 | WP_053287711.1 | hypothetical protein | - |
| CA696_RS24840 | 4747911..4748108 | + | 198 | WP_053287710.1 | DUF957 domain-containing protein | - |
| CA696_RS24845 | 4748192..4749040 | + | 849 | WP_053287709.1 | DUF4942 domain-containing protein | - |
| CA696_RS24850 | 4749093..4749302 | - | 210 | Protein_4558 | hypothetical protein | - |
| CA696_RS24855 | 4749312..4749962 | - | 651 | WP_000056771.1 | 3-keto-L-gulonate-6-phosphate decarboxylase UlaD | - |
| CA696_RS24860 | 4749976..4750440 | - | 465 | WP_000776521.1 | PTS ascorbate transporter subunit IIA | - |
| CA696_RS24865 | 4750450..4750755 | - | 306 | WP_000218360.1 | PTS ascorbate transporter subunit IIB | - |
| CA696_RS24870 | 4750771..4752168 | - | 1398 | WP_001323091.1 | PTS ascorbate transporter subunit IIC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14269.37 Da Isoelectric Point: 7.3006
>T80503 WP_053287712.1 NZ_CP023142:4747029-4747406 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SPCTRSQLINSIDILRARRATGLMTRSHYRMVNNITLGKHCEAKQ
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SPCTRSQLINSIDILRARRATGLMTRSHYRMVNNITLGKHCEAKQ
Download Length: 378 bp
>T80503 NZ_CP023142:4747029-4747406 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGCGGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGAATTC
AGCCCCTGCACCCGCTCTCAGTTAATCAACAGCATTGATATCCTCCGGGCCCGCCGGGCGACCGGCCTGATGACCCGCAG
CCACTACAGAATGGTGAACAACATCACCCTGGGTAAACACTGTGAGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGCGGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGAATTC
AGCCCCTGCACCCGCTCTCAGTTAATCAACAGCATTGATATCCTCCGGGCCCGCCGGGCGACCGGCCTGATGACCCGCAG
CCACTACAGAATGGTGAACAACATCACCCTGGGTAAACACTGTGAGGCGAAACAATGA
Antitoxin
Download Length: 119 a.a. Molecular weight: 13280.07 Da Isoelectric Point: 6.6258
>AT80503 WP_095454386.1 NZ_CP023142:4746582-4746938 [Escherichia coli]
IVSDTLSDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSGELNP
RHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
IVSDTLSDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSGELNP
RHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 357 bp
>AT80503 NZ_CP023142:4746582-4746938 [Escherichia coli]
ATCGTGTCAGACACACTCTCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAGGCCCTGTTTTGG
CGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGCATCAGAGGCCGGTTCAGCGATGCGG
ATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCC
CGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTGTGGTTACGTTTA
TCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
ATCGTGTCAGACACACTCTCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAGGCCCTGTTTTGG
CGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGCATCAGAGGCCGGTTCAGCGATGCGG
ATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCC
CGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTGTGGTTACGTTTA
TCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|