Detailed information of TA system TA080502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4529987..4530801
• Replicon: chromosome
• Accession: NZ_CP023142
• Organism: Escherichia coli strain CFSAN061770

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: CA696_RS23555
• Protein ID: WP_001054376.1
• Coordinates: 4529987..4530244 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: CA696_RS23560
• Protein ID: WP_001309181.1
• Coordinates: 4530256..4530801 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA696_RS23515	4526065..4527045	-	981	WP_000019400.1	IS5-like element IS5 family transposase	-
CA696_RS23520	4527232..4527414	-	183	Protein_4326	hypothetical protein	-
CA696_RS23530	4527470..4528167	+	698	Protein_4327	IS1 family transposase	-
CA696_RS23535	4528183..4529249	-	1067	Protein_4328	helicase YjhR	-
CA696_RS23545	4529365..4529610	+	246	Protein_4329	GNAT family N-acetyltransferase	-
CA696_RS23555	4529987..4530244	+	258	WP_001054376.1	hypothetical protein	Toxin
CA696_RS23560	4530256..4530801	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
CA696_RS23565	4530857..4531603	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
CA696_RS23570	4531772..4531990	+	219	Protein_4333	hypothetical protein	-
CA696_RS30720	4532028..4532144	+	117	Protein_4334	VOC family protein	-
CA696_RS23580	4532389..4533510	+	1122	WP_000010829.1	M42 family metallopeptidase	-
CA696_RS23585	4533507..4533785	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
CA696_RS23590	4533797..4535110	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T80502 WP_001054376.1 NZ_CP023142:4529987-4530244 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T80502 NZ_CP023142:4529987-4530244 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT80502 WP_001309181.1 NZ_CP023142:4530256-4530801 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT80502 NZ_CP023142:4530256-4530801 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8