Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 853316..854151 | Replicon | chromosome |
| Accession | NZ_CP023142 | ||
| Organism | Escherichia coli strain CFSAN061770 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7W3AJH4 |
| Locus tag | CA696_RS04450 | Protein ID | WP_000854721.1 |
| Coordinates | 853316..853693 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A6Y4TI76 |
| Locus tag | CA696_RS04455 | Protein ID | WP_072668294.1 |
| Coordinates | 853783..854151 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CA696_RS04410 | 848465..848700 | - | 236 | Protein_801 | IS110 family transposase | - |
| CA696_RS04420 | 849284..850549 | - | 1266 | WP_095597201.1 | integrase arm-type DNA-binding domain-containing protein | - |
| CA696_RS04425 | 851013..851339 | - | 327 | WP_095597202.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| CA696_RS04430 | 851336..851599 | - | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| CA696_RS04435 | 851671..852537 | - | 867 | WP_095597203.1 | DUF4942 domain-containing protein | - |
| CA696_RS04440 | 852622..852819 | - | 198 | WP_000839291.1 | DUF957 domain-containing protein | - |
| CA696_RS04445 | 852831..853319 | - | 489 | WP_000761677.1 | hypothetical protein | - |
| CA696_RS04450 | 853316..853693 | - | 378 | WP_000854721.1 | TA system toxin CbtA family protein | Toxin |
| CA696_RS04455 | 853783..854151 | - | 369 | WP_072668294.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CA696_RS04460 | 854201..854848 | - | 648 | WP_072668293.1 | antitoxin of toxin-antitoxin stability system | - |
| CA696_RS04465 | 854867..855088 | - | 222 | WP_000692318.1 | DUF987 domain-containing protein | - |
| CA696_RS04470 | 855151..855627 | - | 477 | WP_040089737.1 | RadC family protein | - |
| CA696_RS04475 | 855643..856128 | - | 486 | WP_095597204.1 | antirestriction protein | - |
| CA696_RS04480 | 856219..857037 | - | 819 | WP_095597205.1 | DUF945 domain-containing protein | - |
| CA696_RS04485 | 857223..858107 | - | 885 | WP_000010380.1 | 50S ribosome-binding GTPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 851013..922019 | 71006 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14089.12 Da Isoelectric Point: 8.2904
>T80479 WP_000854721.1 NZ_CP023142:c853693-853316 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T80479 NZ_CP023142:c853693-853316 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13843.53 Da Isoelectric Point: 5.8845
>AT80479 WP_072668294.1 NZ_CP023142:c854151-853783 [Escherichia coli]
VSDSRHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDSRHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT80479 NZ_CP023142:c854151-853783 [Escherichia coli]
GTGTCAGACTCGCGCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACTCGCGCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7W3AJH4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6Y4TI76 |