Detailed information of TA system TA080473

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1556357..1557036
• Replicon: chromosome
• Accession: NZ_CP023140
• Organism: Acinetobacter baumannii strain XH906

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: CK824_RS07385
• Protein ID: WP_000838146.1
• Coordinates: 1556357..1556539 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: CK824_RS07390
• Protein ID: WP_000966688.1
• Coordinates: 1556632..1557036 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CK824_RS18805	1551530..1551700	+	171	WP_005119785.1	hypothetical protein	-
CK824_RS07340	1551712..1552116	+	405	WP_020752395.1	hypothetical protein	-
CK824_RS07345	1552088..1552456	+	369	WP_002154735.1	hypothetical protein	-
CK824_RS07350	1552458..1552856	+	399	WP_038338646.1	hypothetical protein	-
CK824_RS07355	1552858..1553076	+	219	WP_032023387.1	hypothetical protein	-
CK824_RS07360	1553135..1553488	+	354	WP_038338649.1	hypothetical protein	-
CK824_RS07365	1553488..1554474	+	987	WP_038338650.1	hypothetical protein	-
CK824_RS07370	1554527..1555444	+	918	WP_038338651.1	hypothetical protein	-
CK824_RS07375	1555516..1556031	+	516	WP_038338655.1	hypothetical protein	-
CK824_RS07385	1556357..1556539	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
CK824_RS07390	1556632..1557036	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CK824_RS07395	1557135..1557653	+	519	WP_004793706.1	DUF4468 domain-containing protein	-
CK824_RS07400	1557718..1558218	+	501	WP_004793705.1	hypothetical protein	-
CK824_RS18810	1558341..1558499	+	159	WP_004793704.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1527923..1576471	48548

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T80473 WP_000838146.1 NZ_CP023140:1556357-1556539 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T80473 NZ_CP023140:1556357-1556539 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT80473 WP_000966688.1 NZ_CP023140:1556632-1557036 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT80473 NZ_CP023140:1556632-1557036 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6