80468

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2079680..2080194 Replicon chromosome
Accession NZ_CP023076
Organism Staphylococcus argenteus strain XNO62

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7JQI0
Locus tag CJ017_RS10185 Protein ID WP_000233591.1
Coordinates 2079680..2079889 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag CJ017_RS10190 Protein ID WP_000138932.1
Coordinates 2079901..2080194 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJ017_RS10165 2075015..2076379 - 1365 WP_031787694.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
CJ017_RS10170 2076394..2077464 - 1071 WP_031787695.1 D-alanine--D-alanine ligase -
CJ017_RS10175 2077783..2078985 + 1203 WP_031787696.1 rod shape-determining protein RodA -
CJ017_RS10180 2079414..2079551 - 138 WP_000828355.1 hypothetical protein -
CJ017_RS10185 2079680..2079889 - 210 WP_000233591.1 heavy-metal-associated domain-containing protein Toxin
CJ017_RS10190 2079901..2080194 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
CJ017_RS10195 2080362..2081846 + 1485 WP_031787697.1 cardiolipin synthase -
CJ017_RS10200 2081875..2082522 + 648 WP_072692834.1 HD domain-containing protein -
CJ017_RS10210 2083117..2083986 - 870 WP_000725805.1 membrane protein insertase YidC -
CJ017_RS10215 2084072..2084713 - 642 WP_031787699.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7827.81 Da        Isoelectric Point: 4.2681

>T80468 WP_000233591.1 NZ_CP023076:c2079889-2079680 [Staphylococcus argenteus]
MVHQNTIYTAGIETEEQVNQLTERISNMIGVHKVNINIIDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

>T80468 NZ_CP023076:c2079889-2079680 [Staphylococcus argenteus]
ATGGTACATCAAAACACAATATATACTGCAGGTATTGAAACTGAAGAACAAGTAAACCAGTTGACAGAACGTATATCAAA
CATGATAGGTGTGCATAAAGTGAATATTAATATCATTGATGGAGAAGTAGTTGTAGCATATGAAACACCCGCAAATTTAA
ATAGCATTGAAAAAGAAATTTATGATACAGGCTATAAAATTGTATATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT80468 WP_000138932.1 NZ_CP023076:c2080194-2079901 [Staphylococcus argenteus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT80468 NZ_CP023076:c2080194-2079901 [Staphylococcus argenteus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATTAAAACAAATCTTAAATCACGTTTAAATCGAATAGAAGGTCA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTTCTTACACAAATAAGAGCGACGCGTTCTG
CATTAAACAGTGTCGCAATAAAGTTATTAGAGCAACATATGAAAAGTTGTATTATGAATAAAGTAAATCAAGGTGCTCAA
GAAGAAGCGATGGAAGAGTTACTAGTTACTTTTCAAAAGTTGATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQI0

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References