Detailed information of TA system TA080466

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2007567..2008105
• Replicon: chromosome
• Accession: NZ_CP023076
• Organism: Staphylococcus argenteus strain XNO62

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: CJ017_RS09825
• Protein ID: WP_031836919.1
• Coordinates: 2007567..2007893 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: C5QLS5
• Locus tag: CJ017_RS09830
• Protein ID: WP_001058489.1
• Coordinates: 2007896..2008105 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJ017_RS09800	2002712..2003053	-	342	WP_001190615.1	hypothetical protein	-
CJ017_RS09805	2003570..2004211	-	642	WP_100848595.1	pathogenicity island protein	-
CJ017_RS09810	2004208..2004588	-	381	WP_000356927.1	hypothetical protein	-
CJ017_RS09815	2004918..2006618	-	1701	WP_000447470.1	DUF927 domain-containing protein	-
CJ017_RS09820	2006632..2007501	-	870	WP_100848596.1	primase alpha helix C-terminal domain-containing protein	-
CJ017_RS09825	2007567..2007893	-	327	WP_031836919.1	DUF1474 family protein	Toxin
CJ017_RS09830	2007896..2008105	-	210	WP_001058489.1	hypothetical protein	Antitoxin
CJ017_RS09835	2008098..2008244	-	147	WP_000784885.1	hypothetical protein	-
CJ017_RS09840	2008241..2008558	-	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
CJ017_RS09845	2008563..2008781	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
CJ017_RS09850	2008954..2009628	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
CJ017_RS09855	2009642..2010814	+	1173	WP_000179346.1	site-specific integrase	-
CJ017_RS09860	2010883..2012499	-	1617	WP_001118817.1	chaperonin GroEL	-
CJ017_RS09865	2012571..2012855	-	285	WP_031787855.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	1941870..2012855	70985

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13002.40 Da
• Isoelectric Point: 4.3444

>T80466 WP_031836919.1 NZ_CP023076:c2007893-2007567 [Staphylococcus argenteus]
MDWEIKSLFSDLKLLKDSFEDLKDNHGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDAQKLKITE

Nucleotide

• Length: 327 bp

>T80466 NZ_CP023076:c2007893-2007567 [Staphylococcus argenteus]
ATGGATTGGGAAATTAAAAGTTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCGCAGAAATTAAAAATTAC
AGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8225.24 Da
• Isoelectric Point: 4.2820

>AT80466 WP_001058489.1 NZ_CP023076:c2008105-2007896 [Staphylococcus argenteus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT80466 NZ_CP023076:c2008105-2007896 [Staphylococcus argenteus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A853V601