Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1894081..1894868 Replicon chromosome
Accession NZ_CP023076
Organism Staphylococcus argenteus strain XNO62

Toxin (Protein)


Gene name tsbT Uniprot ID A0A7U7PZK3
Locus tag CJ017_RS09140 Protein ID WP_000031103.1
Coordinates 1894081..1894236 (-) Length 52 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A7U7JVF2
Locus tag CJ017_RS09145 Protein ID WP_047430475.1
Coordinates 1894269..1894868 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJ017_RS09120 1889269..1890381 - 1113 WP_031787927.1 GAF domain-containing sensor histidine kinase -
CJ017_RS09125 1890543..1891364 + 822 WP_000669386.1 RluA family pseudouridine synthase -
CJ017_RS09130 1891658..1893043 - 1386 WP_031787928.1 class II fumarate hydratase -
CJ017_RS09135 1893214..1893615 - 402 WP_000901017.1 hypothetical protein -
CJ017_RS09140 1894081..1894236 - 156 WP_000031103.1 hypothetical protein Toxin
CJ017_RS09145 1894269..1894868 - 600 WP_047430475.1 glucosamine-6-phosphate isomerase Antitoxin
CJ017_RS09150 1895027..1895497 - 471 WP_000181399.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
CJ017_RS09155 1895499..1896629 - 1131 WP_031787930.1 tRNA epoxyqueuosine(34) reductase QueG -
CJ017_RS09160 1896780..1897502 - 723 WP_031787931.1 amino acid ABC transporter ATP-binding protein -
CJ017_RS09165 1897495..1898952 - 1458 WP_076692338.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA 1822250..1897502 75252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 6019.42 Da        Isoelectric Point: 4.1469

>T80465 WP_000031103.1 NZ_CP023076:c1894236-1894081 [Staphylococcus argenteus]
MSKDKDAKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKSTDEKNSH

Download         Length: 156 bp

>T80465 NZ_CP023076:c1894236-1894081 [Staphylococcus argenteus]
ATGTCTAAAGATAAAGATGCAAAATTAAATTATCACGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAGATGGAACAAATTTCAGATCAAAATGATCAAGAGAAGAGTACTGATGAAAAGAATAGCCATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22438.57 Da        Isoelectric Point: 5.3935

>AT80465 WP_047430475.1 NZ_CP023076:c1894868-1894269 [Staphylococcus argenteus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDNKKSYFEALGV
PASQIYPIAFEKDAIEFISDKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKKEVVEKLYQENGK
TSFEPSDLKSHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT80465 NZ_CP023076:c1894868-1894269 [Staphylococcus argenteus]
ATGGCAATGAACTTTAAAGTATTTGACAACAGTCAACTTGTAGCAGAATATGCTGCAGATATTATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTGGATACAGACCAAGCACCAGTATTAGATGAACTAAAGAAAAATGTTG
AGAAACACGCTGTTGATTTTAGTCAAATAAATATTTTAGATTATGACAATAAAAAATCTTATTTTGAAGCATTAGGCGTG
CCAGCAAGTCAAATCTATCCAATTGCGTTTGAAAAAGATGCTATTGAATTTATCTCTGACAAAATTAAAACTAAAGAAAA
TAAAGGCAAACTAACATTACAAGTTGTTTCTATTGATGAGCAAGGAAAATTAAATGTTAGTATCCGCCAAGGTTTAATGG
AAGCGAGAGAAATATTTTTAGTTGTGACAGGTGCTAATAAAAAGGAAGTTGTTGAAAAATTATACCAAGAAAATGGTAAA
ACAAGTTTCGAACCATCTGACTTAAAATCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTCAAAGCTTACTTTACATCTCGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7PZK3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7JVF2

References