Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 827967..828444 Replicon chromosome
Accession NZ_CP023076
Organism Staphylococcus argenteus strain XNO62

Toxin (Protein)


Gene name TsaT Uniprot ID A0A7U7JTG2
Locus tag CJ017_RS03965 Protein ID WP_000172413.1
Coordinates 827967..828155 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A7U7JTE3
Locus tag CJ017_RS03970 Protein ID WP_000790107.1
Coordinates 828184..828444 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJ017_RS03925 823547..824029 + 483 WP_031788350.1 hypothetical protein -
CJ017_RS03930 824372..825040 + 669 WP_031788100.1 thermonuclease family protein -
CJ017_RS03935 825404..825604 + 201 WP_001059082.1 cold-shock protein -
CJ017_RS03940 826217..826429 - 213 WP_001007088.1 hypothetical protein -
CJ017_RS03945 826490..826774 - 285 WP_031788101.1 hypothetical protein -
CJ017_RS03950 826863..827432 - 570 WP_031788102.1 hypothetical protein -
CJ017_RS03965 827967..828155 - 189 WP_000172413.1 hypothetical protein Toxin
CJ017_RS03970 828184..828444 - 261 WP_000790107.1 hypothetical protein Antitoxin
CJ017_RS03975 828784..828987 + 204 WP_000145167.1 sterile alpha motif-like domain-containing protein -
CJ017_RS03980 828984..829220 - 237 WP_000368686.1 hypothetical protein -
CJ017_RS03985 829445..830026 + 582 WP_031788103.1 phosphoglycerate mutase family protein -
CJ017_RS03990 830093..830710 - 618 WP_031788104.1 LysE family transporter -
CJ017_RS03995 830874..831365 - 492 WP_000695603.1 GNAT family N-acetyltransferase -
CJ017_RS04000 831772..832194 - 423 WP_001007646.1 organic hydroperoxide resistance protein -
CJ017_RS04005 832343..833062 + 720 WP_047451209.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 812378..906748 94370


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7192.89 Da        Isoelectric Point: 9.9971

>T80460 WP_000172413.1 NZ_CP023076:c828155-827967 [Staphylococcus argenteus]
MTLHFAILFWLALIFIVAGTFIFVLMKKTAKESKKESYLSFAVIFYIFGFAMLIYTLIFGIL

Download         Length: 189 bp

>T80460 NZ_CP023076:c828155-827967 [Staphylococcus argenteus]
ATGACTTTACATTTTGCAATTTTATTTTGGCTAGCATTAATTTTTATCGTTGCTGGTACATTTATATTTGTCTTAATGAA
AAAAACTGCTAAAGAATCTAAAAAAGAATCTTATTTAAGCTTCGCTGTTATTTTCTATATTTTTGGATTCGCAATGCTAA
TTTATACATTAATATTTGGAATTCTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10089.30 Da        Isoelectric Point: 4.1927

>AT80460 WP_000790107.1 NZ_CP023076:c828444-828184 [Staphylococcus argenteus]
MKNIQLNAINLVITIIFAIFNIMITYNKDLDDLCWLLPGIIICGSILIVSFTIAMITKFWLSEILFFINIVLVLYYIYPI
FYDFIN

Download         Length: 261 bp

>AT80460 NZ_CP023076:c828444-828184 [Staphylococcus argenteus]
ATGAAAAACATTCAATTAAATGCTATAAATTTAGTTATAACAATCATATTTGCTATCTTTAACATTATGATTACATATAA
CAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGCATTATCATTTGCGGTTCGATACTCATTGTATCGTTTACCATTG
CAATGATTACTAAATTCTGGTTAAGTGAAATATTATTTTTTATTAACATCGTGCTCGTTCTTTATTATATTTATCCAATT
TTTTATGATTTCATTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JTG2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7JTE3

References