Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/ImmA-HTH_26
Location 899223..899915 Replicon chromosome
Accession NZ_CP023074
Organism Enterococcus thailandicus strain a523

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag CK496_RS04350 Protein ID WP_067484895.1
Coordinates 899223..899567 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag CK496_RS04355 Protein ID WP_071869064.1
Coordinates 899580..899915 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CK496_RS04330 894901..896133 + 1233 WP_075491239.1 30S ribosomal protein S1 -
CK496_RS04335 896322..897632 + 1311 WP_067484889.1 ribosome biogenesis GTPase Der -
CK496_RS04340 897876..898151 + 276 WP_002290178.1 HU family DNA-binding protein -
CK496_RS04345 898531..899136 - 606 WP_071869063.1 DUF5067 domain-containing protein -
CK496_RS04350 899223..899567 - 345 WP_067484895.1 ImmA/IrrE family metallo-endopeptidase Toxin
CK496_RS04355 899580..899915 - 336 WP_071869064.1 helix-turn-helix domain-containing protein Antitoxin
CK496_RS04360 900183..900590 + 408 WP_067484901.1 transcriptional regulator -
CK496_RS04365 900843..901346 + 504 WP_067485098.1 phage major tail protein, TP901-1 family -
CK496_RS04370 901436..901783 + 348 WP_067484904.1 hypothetical protein -
CK496_RS04375 901864..902121 + 258 WP_067485100.1 hypothetical protein -
CK496_RS04380 902137..903762 + 1626 WP_095803517.1 hypothetical protein -
CK496_RS04385 903772..904560 + 789 WP_086271058.1 phage tail family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 897876..927318 29442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(23-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13410.20 Da        Isoelectric Point: 4.9180

>T80457 WP_067484895.1 NZ_CP023074:c899567-899223 [Enterococcus thailandicus]
MKTIKELLASHGIELVVMELEKRGYYFDELKLMVVNQNQSEEKQKQVILHELYHALNHSDFNALYTNPVFHSKMENEANT
SMINYLIQENDGQFNYTSVLEEFNLGLGWECHLK

Download         Length: 345 bp

>T80457 NZ_CP023074:c899567-899223 [Enterococcus thailandicus]
ATGAAAACAATAAAGGAGCTACTCGCTAGTCATGGAATTGAGCTAGTCGTAATGGAATTAGAAAAAAGAGGCTATTATTT
TGATGAGTTGAAACTGATGGTCGTTAATCAAAATCAATCGGAAGAAAAACAAAAACAAGTGATTCTTCATGAACTCTATC
ACGCTCTTAATCATTCAGATTTTAACGCGTTATACACTAATCCTGTCTTCCATTCAAAAATGGAAAACGAAGCAAATACT
TCGATGATTAATTATTTGATTCAAGAAAATGATGGTCAATTCAACTACACAAGTGTGCTAGAAGAATTTAATTTGGGGTT
AGGTTGGGAATGTCACCTGAAATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12620.43 Da        Isoelectric Point: 5.9191

>AT80457 WP_071869064.1 NZ_CP023074:c899915-899580 [Enterococcus thailandicus]
MILYERVSELSKKQGISLNKLAEDIGLSKNVIYQWRTSSPKAETLEKVAEYFHVSVDYLLGRTDTPALGDKVKLPEDLDK
ILDNVKSFDGKPMTDNDREAIRAFLEGRMSK

Download         Length: 336 bp

>AT80457 NZ_CP023074:c899915-899580 [Enterococcus thailandicus]
ATGATTTTATACGAAAGAGTTTCAGAACTTTCAAAAAAACAGGGAATCAGTTTAAACAAACTGGCAGAAGATATTGGATT
ATCTAAAAATGTGATTTATCAGTGGCGAACAAGTAGTCCAAAAGCTGAGACTCTTGAAAAAGTAGCAGAATATTTTCATG
TTTCTGTAGATTATCTGCTTGGACGAACAGATACACCTGCTCTAGGAGATAAAGTAAAACTACCTGAGGATCTCGACAAA
ATTCTAGACAATGTGAAAAGCTTTGATGGAAAACCAATGACTGATAATGACAGAGAGGCCATTCGCGCATTTTTAGAAGG
ACGAATGAGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References