Detailed information of TA system TA080426

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 3291717..3292198
• Replicon: chromosome
• Accession: NZ_CP023061
• Organism: Escherichia coli strain FORC_069

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: FORC69_RS17555
• Protein ID: WP_033812095.1
• Coordinates: 3291908..3292198 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: FORC69_RS17550
• Protein ID: WP_033812094.1
• Coordinates: 3291717..3291908 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC69_RS17500	3286862..3287188	-	327	WP_001369935.1	hypothetical protein	-
FORC69_RS17505	3287189..3287500	-	312	WP_001289674.1	hypothetical protein	-
FORC69_RS17510	3287487..3287792	-	306	WP_001376361.1	DUF4406 domain-containing protein	-
FORC69_RS17515	3287789..3288070	-	282	WP_087614068.1	DNA-binding protein	-
FORC69_RS17520	3288103..3288819	-	717	WP_088888717.1	DUF1627 domain-containing protein	-
FORC69_RS17525	3288853..3289395	-	543	WP_072130322.1	replication protein	-
FORC69_RS27995	3289307..3290338	-	1032	WP_157787303.1	phage replisome organizer	-
FORC69_RS17535	3290407..3290832	-	426	WP_000693925.1	Rha family transcriptional regulator	-
FORC69_RS17540	3290816..3291091	-	276	WP_047083516.1	helix-turn-helix domain-containing protein	-
FORC69_RS17545	3291199..3291699	+	501	WP_033812093.1	helix-turn-helix transcriptional regulator	-
FORC69_RS17550	3291717..3291908	+	192	WP_033812094.1	hypothetical protein	Antitoxin
FORC69_RS17555	3291908..3292198	+	291	WP_033812095.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC69_RS17560	3292467..3292619	+	153	WP_000380319.1	DUF1391 family protein	-
FORC69_RS28000	3292775..3293032	+	258	WP_077637644.1	hypothetical protein	-
FORC69_RS17570	3293113..3293298	-	186	WP_024213805.1	hypothetical protein	-
FORC69_RS17575	3293843..3294031	+	189	WP_000450222.1	cell division inhibitor	-
FORC69_RS17580	3294028..3294216	+	189	WP_086163675.1	DUF1482 family protein	-
FORC69_RS17585	3294309..3296711	+	2403	WP_088888718.1	exonuclease	-
FORC69_RS17590	3296778..3297029	+	252	WP_000273163.1	DUF4224 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11192.05 Da
• Isoelectric Point: 9.9854

>T80426 WP_033812095.1 NZ_CP023061:3291908-3292198 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTTSNIE
IVNVVHSRRQYPNKSC

Nucleotide

• Length: 291 bp

>T80426 NZ_CP023061:3291908-3292198 [Escherichia coli]
ATGCTGCCCATTTTATGGCTACCTTCTGCACGTGATGATTTACGTCAGATAGTAGCCTATATTGCTAAAGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTATCTGTACCCACCGAGCG
AAAGAGTTCCAAGTCTTCGAGAGATAGTGACTCATCCTAACTACATAATACTTTACCGAGTAACAACATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGGCAGTATCCAAACAAAAGCTGTTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 6993.76 Da
• Isoelectric Point: 4.0270

>AT80426 WP_033812094.1 NZ_CP023061:3291717-3291908 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRAKVAASLADPRSGIPHDEVMAEMENLIAQLATTNRSE

Nucleotide

• Length: 192 bp

>AT80426 NZ_CP023061:3291717-3291908 [Escherichia coli]
ATGAGTACAGCCCTTTCCCCGATAATTTCTGAATTTGAAACGGTCGAACAAGAAAACAGCTATAACGAATGGTTGCGAGC
CAAAGTGGCAGCAAGCCTCGCAGATCCCCGTTCTGGAATTCCGCATGATGAAGTAATGGCTGAAATGGAAAACCTTATTG
CTCAATTAGCTACAACGAACAGGAGTGAGTAA