Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3102030..3102828 Replicon chromosome
Accession NZ_CP023061
Organism Escherichia coli strain FORC_069

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3L4GA68
Locus tag FORC69_RS16440 Protein ID WP_000854898.1
Coordinates 3102030..3102407 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3L4GA79
Locus tag FORC69_RS16445 Protein ID WP_001390639.1
Coordinates 3102454..3102828 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC69_RS16405 3097618..3098172 - 555 WP_001001902.1 molecular chaperone YcdY -
FORC69_RS16410 3098196..3098933 - 738 WP_000283664.1 zinc-binding phosphatase -
FORC69_RS16415 3098988..3099926 - 939 WP_000351313.1 glyoxylate/hydroxypyruvate reductase GhrA -
FORC69_RS16425 3100397..3101239 - 843 WP_000014507.1 DUF4942 domain-containing protein -
FORC69_RS16430 3101336..3101533 - 198 WP_000839285.1 DUF957 domain-containing protein -
FORC69_RS16435 3101545..3102033 - 489 WP_000761668.1 hypothetical protein -
FORC69_RS16440 3102030..3102407 - 378 WP_000854898.1 TA system toxin CbtA family protein Toxin
FORC69_RS16445 3102454..3102828 - 375 WP_001390639.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FORC69_RS16450 3102908..3103129 - 222 WP_000692352.1 DUF987 domain-containing protein -
FORC69_RS16455 3103216..3103692 - 477 WP_001186776.1 RadC family protein -
FORC69_RS16460 3103708..3104193 - 486 WP_000213691.1 antirestriction protein -
FORC69_RS16465 3104285..3105103 - 819 WP_001234635.1 DUF945 domain-containing protein -
FORC69_RS27965 3105197..3105375 + 179 Protein_3011 hypothetical protein -
FORC69_RS16480 3105514..3105927 - 414 WP_000789536.1 hypothetical protein -
FORC69_RS16485 3106197..3106736 - 540 WP_001104026.1 DUF4339 domain-containing protein -
FORC69_RS16490 3106862..3107320 - 459 WP_000771527.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14050.07 Da        Isoelectric Point: 8.5190

>T80425 WP_000854898.1 NZ_CP023061:c3102407-3102030 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWKTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T80425 NZ_CP023061:c3102407-3102030 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGAAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGATGCAGTGAATTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13566.36 Da        Isoelectric Point: 6.0568

>AT80425 WP_001390639.1 NZ_CP023061:c3102828-3102454 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTATLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT80425 NZ_CP023061:c3102828-3102454 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGACATCAGCATACCGCCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAACCACTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L4GA68

Antitoxin

Source ID Structure
AlphaFold DB A0A3L4GA79

References