Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 644240..644780 Replicon chromosome
Accession NZ_CP023055
Organism Vibrio anguillarum strain VIB43

Toxin (Protein)


Gene name relE Uniprot ID A0A289GHH1
Locus tag CK207_RS18480 Protein ID WP_069212181.1
Coordinates 644511..644780 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A233HK77
Locus tag CK207_RS18475 Protein ID WP_019283191.1
Coordinates 644240..644518 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CK207_RS18435 640198..640605 - 408 WP_175418697.1 hypothetical protein -
CK207_RS18440 640654..640746 - 93 WP_140288197.1 DUF3265 domain-containing protein -
CK207_RS18445 640861..641829 + 969 WP_081245536.1 IS30 family transposase -
CK207_RS18450 641864..642334 - 471 WP_019282925.1 hypothetical protein -
CK207_RS18460 642537..642950 - 414 WP_019283386.1 RDD family protein -
CK207_RS18465 643737..643973 + 237 WP_013867767.1 hypothetical protein -
CK207_RS18470 644073..644183 - 111 WP_094164944.1 DUF3265 domain-containing protein -
CK207_RS18475 644240..644518 + 279 WP_019283191.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CK207_RS18480 644511..644780 + 270 WP_069212181.1 type II toxin-antitoxin system YafQ family toxin Toxin
CK207_RS18490 645395..645715 + 321 WP_081245520.1 IS66 family insertion sequence hypothetical protein -
CK207_RS18495 645712..646065 + 354 WP_069212062.1 IS66 family insertion sequence element accessory protein TnpB -
CK207_RS18500 646125..647657 + 1533 WP_095661379.1 IS66-like element ISVa9 family transposase -
CK207_RS18505 647688..647960 - 273 Protein_624 transposase -
CK207_RS18510 648037..649392 - 1356 WP_019282651.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 622341..647960 25619
- inside Integron - - 624024..644923 20899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-84)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10236.89 Da        Isoelectric Point: 8.9357

>T80405 WP_069212181.1 NZ_CP023055:644511-644780 [Vibrio anguillarum]
MYSLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLDPKNVDHPLTGGWVGFRDCHVKPDLVLIYRIFDGQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T80405 NZ_CP023055:644511-644780 [Vibrio anguillarum]
ATGTATAGTTTAGAATACTCAACACAATTCAAAAAAGACTTTAAAAAAATCACCAAAATGCCGATTTCGGACATCATTGA
AGTCGGCAACGTCATATCAAAGCTGCAAAGAGGCGAAAAACTCGATCCTAAAAATGTTGATCATCCTTTAACTGGCGGAT
GGGTTGGATTCCGAGACTGTCACGTTAAACCAGATCTAGTGCTCATTTATCGCATTTTTGATGGTCAACTCCAATTAGCT
AGAATTGGCTCTCATAGTGATTTGTTCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9995.47 Da        Isoelectric Point: 6.4761

>AT80405 WP_019283191.1 NZ_CP023055:644240-644518 [Vibrio anguillarum]
MRTEMLSTRIDHDTKVAFTSICDEMGLSTSQAIKIFAKAVINHGGIPFDLRVPQPNETTISAMNELVQGHGHKAESVGAM
LTELTEGKVKNV

Download         Length: 279 bp

>AT80405 NZ_CP023055:644240-644518 [Vibrio anguillarum]
ATGAGAACAGAAATGCTAAGTACTCGCATAGACCATGATACCAAAGTTGCTTTTACTAGCATCTGTGACGAAATGGGTCT
TAGTACATCACAAGCTATTAAAATTTTTGCAAAAGCCGTGATTAATCATGGTGGTATTCCATTTGATTTACGTGTACCTC
AACCAAATGAAACAACGATTTCTGCAATGAATGAACTCGTTCAAGGTCATGGACATAAAGCCGAATCTGTTGGCGCTATG
CTTACTGAGCTAACTGAAGGCAAAGTTAAGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A289GHH1

Antitoxin

Source ID Structure
AlphaFold DB A0A233HK77

References