Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 519867..520416 Replicon chromosome
Accession NZ_CP023055
Organism Vibrio anguillarum strain VIB43

Toxin (Protein)


Gene name parE Uniprot ID A0A191WAE5
Locus tag CK207_RS17785 Protein ID WP_017049509.1
Coordinates 519867..520166 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A233HQC6
Locus tag CK207_RS17790 Protein ID WP_017045808.1
Coordinates 520174..520416 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CK207_RS17750 515557..515937 + 381 Protein_481 GNAT family N-acetyltransferase -
CK207_RS17755 515956..516924 - 969 WP_081245537.1 IS30 family transposase -
CK207_RS17760 517109..517375 + 267 WP_081245529.1 dihydrofolate reductase family protein -
CK207_RS17765 517510..518025 + 516 WP_029388222.1 lipocalin family protein -
CK207_RS17770 518166..518639 + 474 WP_019282174.1 GNAT family N-acetyltransferase -
CK207_RS20805 518630..518746 + 117 Protein_486 DUF3265 domain-containing protein -
CK207_RS17780 519235..519699 + 465 WP_017046620.1 GNAT family N-acetyltransferase -
CK207_RS17785 519867..520166 - 300 WP_017049509.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CK207_RS17790 520174..520416 - 243 WP_017045808.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CK207_RS17795 520659..521809 + 1151 WP_095661212.1 IS3 family transposase -
CK207_RS20810 521839..521919 + 81 Protein_491 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CK207_RS17800 521982..523163 + 1182 WP_019282469.1 aspartate/tyrosine/aromatic aminotransferase -
CK207_RS17805 523192..523812 + 621 WP_019282470.1 ATP-dependent zinc protease -
CK207_RS17810 524128..525075 + 948 WP_038148427.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 480904..521809 40905


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-47)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11412.09 Da        Isoelectric Point: 9.8456

>T80403 WP_017049509.1 NZ_CP023055:c520166-519867 [Vibrio anguillarum]
MHKSKYKLSKLAQAHLHKIKNYTVTNFSEMQWNAYKDTLLTGFQMLADNPAVGRSCNDLYQNGFYFPIGKHTAYFTKEDS
FILVVAVLGQSQLPQNHLR

Download         Length: 300 bp

>T80403 NZ_CP023055:c520166-519867 [Vibrio anguillarum]
ATGCACAAGAGTAAATATAAACTAAGTAAATTAGCACAGGCTCATTTACATAAAATCAAAAATTATACCGTTACAAACTT
TTCCGAGATGCAGTGGAACGCATACAAAGACACTCTTCTTACTGGGTTTCAGATGCTCGCTGACAACCCCGCTGTAGGCA
GAAGCTGCAACGATTTATATCAAAATGGTTTTTACTTCCCTATAGGCAAGCATACGGCTTACTTTACCAAGGAAGACAGT
TTTATTTTGGTCGTTGCAGTCCTTGGGCAATCGCAATTGCCACAAAACCATCTGCGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9036.28 Da        Isoelectric Point: 4.7672

>AT80403 WP_017045808.1 NZ_CP023055:c520416-520174 [Vibrio anguillarum]
MYTLTANDAKRNFGELLLNAQREPVKISKNNKDAVVVMSIRDYEELEVMKADYIKHCFESAKADLAQGNIVDGENFLNAL

Download         Length: 243 bp

>AT80403 NZ_CP023055:c520416-520174 [Vibrio anguillarum]
ATGTACACATTAACAGCAAATGATGCCAAACGTAATTTCGGTGAACTGCTTCTAAACGCTCAACGTGAGCCAGTTAAAAT
TAGTAAAAACAATAAAGATGCCGTTGTTGTGATGTCGATTAGAGACTATGAAGAACTTGAAGTCATGAAAGCCGATTACA
TAAAACATTGTTTTGAGTCCGCAAAAGCAGACTTAGCCCAAGGCAATATAGTTGACGGTGAAAACTTCCTAAACGCGTTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A191WAE5

Antitoxin

Source ID Structure
AlphaFold DB A0A233HQC6

References