Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 461536..462046 Replicon chromosome
Accession NZ_CP023055
Organism Vibrio anguillarum strain VIB43

Toxin (Protein)


Gene name relB Uniprot ID A0A289GH26
Locus tag CK207_RS17380 Protein ID WP_009836584.1
Coordinates 461783..462046 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7T0WJM7
Locus tag CK207_RS17375 Protein ID WP_019283323.1
Coordinates 461536..461790 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CK207_RS17350 456741..458273 + 1533 WP_069211897.1 IS66-like element ISVa11 family transposase -
CK207_RS17355 458535..458888 - 354 Protein_419 transposase -
CK207_RS17360 458972..459292 + 321 WP_081245520.1 IS66 family insertion sequence hypothetical protein -
CK207_RS17365 459289..459642 + 354 WP_069212062.1 IS66 family insertion sequence element accessory protein TnpB -
CK207_RS17370 459702..461234 + 1533 WP_069212063.1 IS66-like element ISVa9 family transposase -
CK207_RS17375 461536..461790 + 255 WP_019283323.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CK207_RS17380 461783..462046 + 264 WP_009836584.1 Txe/YoeB family addiction module toxin Toxin
CK207_RS17385 462337..463305 - 969 WP_095661356.1 IS30 family transposase -
CK207_RS17395 463404..463577 + 174 Protein_426 GNAT family N-acetyltransferase -
CK207_RS17400 463585..464556 - 972 WP_019282910.1 IS110 family transposase -
CK207_RS17405 464777..464869 + 93 WP_140286978.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 451369..475643 24274
- inside Integron - - 459702..468696 8994


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10302.63 Da        Isoelectric Point: 8.8578

>T80402 WP_009836584.1 NZ_CP023055:461783-462046 [Vibrio anguillarum]
MSSRLLSWTDESWNDYVYWQTQDKKTLKRINKLITDAKRSPFEGIGKPEPLKENLSGFWSRRIDDANRLVYAVDDSAITI
ISCRYHY

Download         Length: 264 bp

>T80402 NZ_CP023055:461783-462046 [Vibrio anguillarum]
ATGAGTAGTCGTTTATTATCTTGGACTGATGAATCTTGGAATGATTATGTTTATTGGCAGACGCAAGACAAGAAAACACT
TAAACGTATAAATAAACTCATCACGGATGCTAAGCGTTCTCCTTTCGAGGGCATAGGTAAACCTGAGCCACTAAAAGAAA
ACTTATCTGGTTTTTGGTCGCGACGAATAGACGATGCGAATAGGTTAGTTTATGCGGTTGATGATAGTGCTATCACGATT
ATTTCTTGCCGTTATCACTATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9434.60 Da        Isoelectric Point: 5.5802

>AT80402 WP_019283323.1 NZ_CP023055:461536-461790 [Vibrio anguillarum]
MRIVSFTEARNSLKSVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLHRSIAQFKAGKASQRD
LIDE

Download         Length: 255 bp

>AT80402 NZ_CP023055:461536-461790 [Vibrio anguillarum]
ATGAGAATTGTATCTTTTACAGAAGCTAGAAATAGCTTGAAGAGCGTTTTGGATGCTGTTGTTAATGACGCAGATACAAC
CGTGATCACACGTCGTGATTCTGAAGATGCCGTTGTTATGTCACTGGATTATTACAATAGCTTAATGGAAACGGTTCATT
TACTTCGTTCTCCGGCAAATGCTGAGCACTTACATCGTTCAATTGCTCAATTTAAAGCGGGTAAGGCGAGCCAAAGAGAT
TTAATCGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A289GH26

Antitoxin

Source ID Structure
AlphaFold DB A0A7T0WJM7

References