Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 425390..425928 Replicon chromosome
Accession NZ_CP023055
Organism Vibrio anguillarum strain VIB43

Toxin (Protein)


Gene name parE Uniprot ID A0A7X8U0Q7
Locus tag CK207_RS17080 Protein ID WP_019282621.1
Coordinates 425390..425689 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A289GHF4
Locus tag CK207_RS17085 Protein ID WP_019282620.1
Coordinates 425686..425928 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CK207_RS17055 420710..421912 + 1203 WP_029388116.1 DUF3800 domain-containing protein -
CK207_RS17060 422106..423638 - 1533 WP_069212063.1 IS66-like element ISVa9 family transposase -
CK207_RS17065 423698..424051 - 354 WP_069212062.1 IS66 family insertion sequence element accessory protein TnpB -
CK207_RS17070 424048..424368 - 321 WP_081245520.1 IS66 family insertion sequence hypothetical protein -
CK207_RS17075 424450..425339 + 890 Protein_373 IS256 family transposase -
CK207_RS17080 425390..425689 - 300 WP_019282621.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CK207_RS17085 425686..425928 - 243 WP_019282620.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CK207_RS17090 426023..426991 - 969 WP_081245536.1 IS30 family transposase -
CK207_RS17100 427232..427747 + 516 WP_019283453.1 peptide deformylase -
CK207_RS17115 429538..430251 + 714 WP_019283452.1 Fic family protein -
CK207_RS20760 430248..430358 + 111 Protein_379 DUF3265 domain-containing protein -
CK207_RS17120 430408..430785 + 378 WP_019283451.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 386109..446342 60233
- inside Integron - - 427232..442955 15723


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11662.38 Da        Isoelectric Point: 9.8917

>T80398 WP_019282621.1 NZ_CP023055:c425689-425390 [Vibrio anguillarum]
MKPFQLTNKAKSDLKDIALFTSRRWGREQRNIYLKQFDESFWLLAENPDIGKTCDEIRDGYRKFPQGSHVIFYQQIGSQN
IQIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T80398 NZ_CP023055:c425689-425390 [Vibrio anguillarum]
ATGAAACCATTCCAACTAACCAACAAGGCAAAATCCGATTTAAAAGATATTGCCTTATTTACCTCTCGCAGGTGGGGCCG
CGAGCAACGAAATATTTATCTCAAACAATTCGATGAATCATTTTGGCTACTCGCTGAAAATCCTGATATCGGTAAAACTT
GTGATGAAATCAGAGATGGCTACCGAAAATTTCCACAAGGAAGCCATGTTATTTTTTATCAACAAATTGGTAGCCAAAAC
ATCCAGATCATAAGAATCTTGCATAAGAGTATGGATGTAAATCCAATCTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8946.90 Da        Isoelectric Point: 4.3085

>AT80398 WP_019282620.1 NZ_CP023055:c425928-425686 [Vibrio anguillarum]
MAKNTSITLGDHFDGFISSQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGMADYDLNSFISELDSEERK

Download         Length: 243 bp

>AT80398 NZ_CP023055:c425928-425686 [Vibrio anguillarum]
ATGGCTAAAAATACTAGCATCACTCTCGGCGACCACTTTGATGGTTTCATTAGTAGCCAAATCCAAAGTGGACGCTATGG
CTCAGCAAGTGAAGTAATTCGTTCCGCTCTACGTTTACTCGAAACACAAGAAACGAAAATGAACACTTTACGACAACTGC
TCGTTGAAGGTGAAGAAAGTGGTATGGCTGATTATGACCTCAATTCGTTTATCAGTGAACTAGATAGTGAAGAAAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X8U0Q7

Antitoxin

Source ID Structure
AlphaFold DB A0A289GHF4

References