Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 796078..796674 | Replicon | chromosome |
Accession | NZ_CP023046 | ||
Organism | Mannheimia haemolytica strain USDA-ARS-USMARC-187 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | CKG21_RS04020 | Protein ID | WP_006249776.1 |
Coordinates | 796450..796674 (-) | Length | 75 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A547EKP0 |
Locus tag | CKG21_RS04015 | Protein ID | WP_006249777.1 |
Coordinates | 796078..796407 (-) | Length | 110 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CKG21_RS03990 | 791527..792216 | + | 690 | WP_006253589.1 | GTP cyclohydrolase I FolE | - |
CKG21_RS03995 | 792281..793066 | + | 786 | WP_006249781.1 | tRNA pseudouridine(38-40) synthase TruA | - |
CKG21_RS04000 | 793119..795311 | - | 2193 | WP_006249780.1 | copper-translocating P-type ATPase | - |
CKG21_RS04005 | 795364..795564 | - | 201 | WP_006249779.1 | heavy-metal-associated domain-containing protein | - |
CKG21_RS04010 | 795653..796039 | + | 387 | WP_006249778.1 | Cu(I)-responsive transcriptional regulator | - |
CKG21_RS04015 | 796078..796407 | - | 330 | WP_006249777.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
CKG21_RS04020 | 796450..796674 | - | 225 | WP_006249776.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
CKG21_RS04025 | 796882..798789 | + | 1908 | WP_006249774.1 | DNA topoisomerase IV subunit B | - |
CKG21_RS04030 | 798863..799468 | - | 606 | WP_006249773.1 | glycerol-3-phosphate 1-O-acyltransferase PlsY | - |
CKG21_RS04035 | 799538..799894 | + | 357 | WP_006249772.1 | dihydroneopterin aldolase | - |
CKG21_RS04040 | 799891..800793 | + | 903 | WP_006249771.1 | DMT family transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 75 a.a. Molecular weight: 8612.00 Da Isoelectric Point: 10.5597
>T80382 WP_006249776.1 NZ_CP023046:c796674-796450 [Mannheimia haemolytica]
MVVKILKRKSQKTLQQIYTQPISANIKWTNIEALFLELGAEIEEREGSRIAVVLFQQVRVFHRPHPNPDTDKGR
MVVKILKRKSQKTLQQIYTQPISANIKWTNIEALFLELGAEIEEREGSRIAVVLFQQVRVFHRPHPNPDTDKGR
Download Length: 225 bp
>T80382 NZ_CP023046:c796674-796450 [Mannheimia haemolytica]
ATGGTAGTAAAAATCCTAAAGCGGAAATCTCAAAAGACACTACAACAAATCTACACCCAGCCTATTTCTGCCAATATTAA
ATGGACAAATATAGAAGCTCTTTTTCTAGAGTTAGGAGCAGAAATAGAAGAACGAGAAGGGAGCAGAATTGCAGTTGTTT
TATTTCAACAGGTCAGAGTATTTCATCGCCCACACCCGAATCCTGATACAGATAAGGGGCGGTAG
ATGGTAGTAAAAATCCTAAAGCGGAAATCTCAAAAGACACTACAACAAATCTACACCCAGCCTATTTCTGCCAATATTAA
ATGGACAAATATAGAAGCTCTTTTTCTAGAGTTAGGAGCAGAAATAGAAGAACGAGAAGGGAGCAGAATTGCAGTTGTTT
TATTTCAACAGGTCAGAGTATTTCATCGCCCACACCCGAATCCTGATACAGATAAGGGGCGGTAG
Antitoxin
Download Length: 110 a.a. Molecular weight: 12312.06 Da Isoelectric Point: 4.7022
>AT80382 WP_006249777.1 NZ_CP023046:c796407-796078 [Mannheimia haemolytica]
MRNIMDINGYKAVIAYDPETELFRGEFIGLNGGADFYADNVIQLKKEGELSLNIFLELCREKGIEPFKQYSGKFNVRLSP
ELHKAAVIAATAENLSLNEWINQTLEKSV
MRNIMDINGYKAVIAYDPETELFRGEFIGLNGGADFYADNVIQLKKEGELSLNIFLELCREKGIEPFKQYSGKFNVRLSP
ELHKAAVIAATAENLSLNEWINQTLEKSV
Download Length: 330 bp
>AT80382 NZ_CP023046:c796407-796078 [Mannheimia haemolytica]
ATGCGTAATATTATGGATATTAATGGTTATAAAGCTGTCATTGCTTACGATCCCGAAACAGAATTATTTCGAGGTGAATT
TATCGGATTAAATGGTGGAGCCGATTTTTATGCCGATAATGTCATTCAATTAAAAAAAGAAGGTGAACTAAGTTTGAATA
TCTTTTTAGAACTTTGTAGAGAAAAAGGTATTGAGCCGTTCAAACAATATTCCGGAAAGTTTAATGTTCGCCTTTCGCCT
GAATTACATAAAGCTGCGGTAATTGCAGCAACTGCTGAAAATTTAAGCTTAAATGAATGGATTAACCAAACGTTAGAAAA
GAGCGTGTAG
ATGCGTAATATTATGGATATTAATGGTTATAAAGCTGTCATTGCTTACGATCCCGAAACAGAATTATTTCGAGGTGAATT
TATCGGATTAAATGGTGGAGCCGATTTTTATGCCGATAATGTCATTCAATTAAAAAAAGAAGGTGAACTAAGTTTGAATA
TCTTTTTAGAACTTTGTAGAGAAAAAGGTATTGAGCCGTTCAAACAATATTCCGGAAAGTTTAATGTTCGCCTTTCGCCT
GAATTACATAAAGCTGCGGTAATTGCAGCAACTGCTGAAAATTTAAGCTTAAATGAATGGATTAACCAAACGTTAGAAAA
GAGCGTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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