Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 92981..93657 Replicon plasmid unnamed3
Accession NZ_CP023039
Organism Komagataeibacter saccharivorans strain CV1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CD178_RS16885 Protein ID WP_110548428.1
Coordinates 92981..93391 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CD178_RS16890 Protein ID WP_110548427.1
Coordinates 93388..93657 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD178_RS16850 88393..89043 - 651 WP_174234183.1 MucR family transcriptional regulator -
CD178_RS16855 89436..89825 - 390 WP_110548357.1 hypothetical protein -
CD178_RS16860 89818..90021 - 204 WP_110548356.1 hypothetical protein -
CD178_RS16865 90247..90507 + 261 WP_174234184.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CD178_RS16870 90504..90920 + 417 WP_110548355.1 type II toxin-antitoxin system VapC family toxin -
CD178_RS16875 90966..92186 - 1221 WP_118963867.1 transposase -
CD178_RS16880 92209..92622 + 414 WP_110548459.1 IS200/IS605 family transposase -
CD178_RS16885 92981..93391 - 411 WP_110548428.1 type II toxin-antitoxin system VapC family toxin Toxin
CD178_RS16890 93388..93657 - 270 WP_110548427.1 antitoxin Antitoxin
CD178_RS16895 93961..94638 + 678 WP_110548426.1 hypothetical protein -
CD178_RS16900 94706..95389 + 684 WP_110548425.1 RES family NAD+ phosphorylase -
CD178_RS16905 95621..96532 + 912 WP_110548424.1 tyrosine-type recombinase/integrase -
CD178_RS16910 96558..97736 + 1179 WP_110548429.1 IS91 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..127836 127836
- flank IS/Tn - - 92209..92622 413


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-125)

Antitoxin

SpoVT-AbrB domain

(18-63)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14287.57 Da        Isoelectric Point: 4.5083

>T80360 WP_110548428.1 NZ_CP023039:c93391-92981 [Komagataeibacter saccharivorans]
VTALFMLDTNIISDLARNPQGMVARHIVSVGDDAICVSVITAAELRYGCVKKGSPKLMAQIEAILENTTVLALELPVDAE
YGRIRADLEAAGTPIGPNDLLIAAHACAVGAVLVTANTGEFERVCGLKVENWLATA

Download         Length: 411 bp

>T80360 NZ_CP023039:c93391-92981 [Komagataeibacter saccharivorans]
GTGACCGCGCTCTTCATGTTGGACACCAATATCATCTCTGATCTGGCCCGGAATCCTCAGGGTATGGTCGCTCGACATAT
CGTGTCTGTCGGTGACGACGCGATATGCGTCAGCGTCATTACCGCCGCCGAACTTCGTTATGGCTGCGTGAAGAAGGGCT
CGCCGAAACTGATGGCGCAGATCGAGGCGATCTTGGAGAACACCACCGTGCTCGCCCTTGAGCTCCCTGTCGACGCTGAA
TACGGCCGCATCCGGGCGGATCTCGAGGCGGCCGGAACGCCGATCGGCCCGAACGATCTCTTAATTGCCGCTCATGCTTG
TGCCGTCGGCGCGGTACTCGTCACCGCCAACACTGGTGAGTTCGAGCGTGTATGTGGCCTGAAGGTCGAAAACTGGCTCG
CCACTGCGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10096.63 Da        Isoelectric Point: 5.6277

>AT80360 WP_110548427.1 NZ_CP023039:c93657-93388 [Komagataeibacter saccharivorans]
MHYHRQLDASPPREAKLFRNNKSQAVRIPVDFELPGERVLIHREGSRLIIEPVPGKRLLAVLAELEPLPPEDAFPDVDST
LLPARDIDL

Download         Length: 270 bp

>AT80360 NZ_CP023039:c93657-93388 [Komagataeibacter saccharivorans]
ATGCATTACCATCGCCAGCTGGATGCCTCGCCCCCGCGTGAGGCCAAACTCTTTCGGAACAACAAGAGCCAGGCGGTTCG
CATTCCGGTCGACTTCGAGCTTCCCGGTGAGCGGGTGCTGATACACCGGGAGGGGTCACGGCTAATCATCGAACCTGTGC
CTGGAAAGCGTTTGTTGGCCGTCCTTGCTGAACTGGAGCCACTACCACCCGAAGACGCTTTTCCCGATGTCGACAGCACA
CTTCTGCCGGCGCGGGACATCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References