Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 53575..54146 Replicon plasmid unnamed3
Accession NZ_CP023039
Organism Komagataeibacter saccharivorans strain CV1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CD178_RS16685 Protein ID WP_110548243.1
Coordinates 53817..54146 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CD178_RS16680 Protein ID WP_110548244.1
Coordinates 53575..53817 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD178_RS17820 49636..49911 + 276 WP_146220142.1 hypothetical protein -
CD178_RS16670 49908..53093 + 3186 WP_110548246.1 relaxase domain-containing protein -
CD178_RS16675 53134..53454 + 321 WP_110548245.1 hypothetical protein -
CD178_RS16680 53575..53817 + 243 WP_110548244.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CD178_RS16685 53817..54146 + 330 WP_110548243.1 endoribonuclease MazF Toxin
CD178_RS16690 54229..54849 - 621 WP_039733240.1 NIPSNAP family protein -
CD178_RS16695 54846..55190 - 345 WP_171789708.1 hypothetical protein -
CD178_RS16700 55307..56203 + 897 WP_082084838.1 LysR family transcriptional regulator -
CD178_RS16705 56379..57206 - 828 WP_110548242.1 S-formylglutathione hydrolase -
CD178_RS16710 57231..57632 - 402 WP_039733238.1 VOC family protein -
CD178_RS16715 57692..58801 - 1110 WP_039733241.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
CD178_RS16720 58843..59118 - 276 WP_025829448.1 formaldehyde-responsive transcriptional repressor FrmR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..127836 127836


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-108)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12015.88 Da        Isoelectric Point: 9.2801

>T80358 WP_110548243.1 NZ_CP023039:53817-54146 [Komagataeibacter saccharivorans]
MPEWVPDCGDIVWLEFDPQAGREQAGHRPAVVLSPASYNAKSGMIVCCPTTTRIKSYPFEVPLQGQPASVVLSDQVRSLD
WRARRAKKKGKVAGGELEAVRERVRLLVG

Download         Length: 330 bp

>T80358 NZ_CP023039:53817-54146 [Komagataeibacter saccharivorans]
ATGCCGGAATGGGTACCAGACTGTGGGGACATCGTGTGGCTCGAGTTTGATCCTCAGGCAGGTCGTGAACAGGCGGGGCA
CCGGCCTGCCGTGGTGCTATCGCCTGCTTCGTACAACGCAAAGTCAGGCATGATCGTCTGCTGCCCGACGACCACGCGCA
TCAAAAGCTACCCGTTCGAAGTGCCCCTTCAAGGGCAGCCTGCGAGCGTCGTGCTGTCTGATCAGGTCAGAAGCCTCGAT
TGGCGTGCCCGCCGCGCCAAAAAGAAAGGCAAGGTTGCGGGGGGCGAGCTTGAAGCTGTCCGCGAGCGAGTACGTCTCCT
GGTCGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8825.94 Da        Isoelectric Point: 4.7469

>AT80358 WP_110548244.1 NZ_CP023039:53575-53817 [Komagataeibacter saccharivorans]
MHGTVRKWGNSAAIRLPTSILEAVQLQIDQSVDVREEDGRIIIQPLRRESLSLESLTAAITDENRHGEMGFGPSVGGEVW

Download         Length: 243 bp

>AT80358 NZ_CP023039:53575-53817 [Komagataeibacter saccharivorans]
ATGCACGGAACTGTACGCAAATGGGGCAATAGCGCCGCCATTCGTCTGCCAACGAGCATTCTCGAAGCTGTCCAGCTTCA
GATCGATCAATCCGTTGACGTTCGAGAGGAAGATGGGCGGATTATCATCCAGCCTCTTCGTCGGGAAAGCCTTTCTCTGG
AAAGCCTGACGGCGGCGATCACGGACGAAAACCGCCACGGTGAGATGGGCTTTGGGCCTTCAGTCGGCGGTGAGGTCTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References