Detailed information of TA system TA080351

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2229474..2230153
• Replicon: chromosome
• Accession: NZ_CP023031
• Organism: Acinetobacter baumannii strain 7847

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: Aba7847_RS10625
• Protein ID: WP_000838146.1
• Coordinates: 2229474..2229656 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: Aba7847_RS10630
• Protein ID: WP_000966688.1
• Coordinates: 2229749..2230153 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aba7847_RS10580	2224547..2224951	+	405	WP_000247948.1	hypothetical protein	-
Aba7847_RS10585	2224923..2225291	+	369	WP_002055488.1	hypothetical protein	-
Aba7847_RS10590	2225293..2225691	+	399	WP_001251850.1	hypothetical protein	-
Aba7847_RS10595	2225693..2225911	+	219	WP_001277687.1	hypothetical protein	-
Aba7847_RS10600	2226005..2226358	+	354	WP_000064599.1	hypothetical protein	-
Aba7847_RS10605	2226358..2227593	+	1236	WP_000002422.1	hypothetical protein	-
Aba7847_RS10610	2227646..2228563	+	918	WP_000094250.1	hypothetical protein	-
Aba7847_RS10615	2228633..2229148	+	516	WP_001185608.1	hypothetical protein	-
Aba7847_RS10625	2229474..2229656	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
Aba7847_RS10630	2229749..2230153	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Aba7847_RS10635	2230252..2230428	+	177	WP_014466185.1	hypothetical protein	-
Aba7847_RS10640	2230437..2230760	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
Aba7847_RS10645	2230792..2231586	+	795	WP_000720608.1	hypothetical protein	-
Aba7847_RS10650	2231635..2231874	-	240	WP_000763623.1	Arc family DNA-binding protein	-
Aba7847_RS10655	2231997..2232152	+	156	WP_001103649.1	Arc family DNA-binding protein	-
Aba7847_RS10660	2232149..2233141	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2207304..2257338	50034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T80351 WP_000838146.1 NZ_CP023031:2229474-2229656 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T80351 NZ_CP023031:2229474-2229656 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT80351 WP_000966688.1 NZ_CP023031:2229749-2230153 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT80351 NZ_CP023031:2229749-2230153 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6