Detailed information of TA system TA080350

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1092660..1093313
• Replicon: chromosome
• Accession: NZ_CP023031
• Organism: Acinetobacter baumannii strain 7847

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: Aba7847_RS05285
• Protein ID: WP_000607077.1
• Coordinates: 1092924..1093313 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: Aba7847_RS05280
• Protein ID: WP_001288210.1
• Coordinates: 1092660..1092917 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aba7847_RS05260	1088176..1089183	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
Aba7847_RS05265	1089202..1089579	+	378	WP_001216380.1	50S ribosomal protein L17	-
Aba7847_RS05270	1089761..1091251	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
Aba7847_RS05275	1091300..1092472	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
Aba7847_RS05280	1092660..1092917	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
Aba7847_RS05285	1092924..1093313	+	390	WP_000607077.1	membrane protein	Toxin
Aba7847_RS05290	1094083..1095168	+	1086	WP_000049106.1	hypothetical protein	-
Aba7847_RS05295	1095246..1095812	+	567	WP_000651538.1	rhombosortase	-
Aba7847_RS05300	1096000..1098195	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T80350 WP_000607077.1 NZ_CP023031:1092924-1093313 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T80350 NZ_CP023031:1092924-1093313 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT80350 WP_001288210.1 NZ_CP023031:1092660-1092917 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT80350 NZ_CP023031:1092660-1092917 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7